EsCitalopram EP Impurity H CAS 63284-72-0
| CAS No. | 63284-72-0 |
| Molecular Formula | C20H21FN2O2 |
| Molecular Weight | 340.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
EsCitalopram EP Impurity H (CAS 63284-72-0) is a certified pharmaceutical impurity reference standard with the molecular formula C20H21FN2O2 and a molecular weight of 340.39 g/mol.
The molecular framework of EsCitalopram EP Impurity H (C20H21FN2O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H21FN2O2 |
| Molecular Weight | 340.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related EsCitalopram Standards
- ESCitalopram N-Oxide (CAS 917482-45-2)
- EsCitalopram Impurity 3 (CAS CATO-C4X-16343)
- Escitalopram EP Impurity A(R-Isomer) (CAS CATO-C4X-110920)
- Escitalopram Impurity 2 (CAS 103146-25-4)
- Escitalopram EP Impurity M (CAS 1881237-26-8)
- Escitalopram EP Impurity K (CAS 128196-02-1)
- EsCitalopram EP Impurity I (CAS 1370643-22-3)
- Escitalopram EP Impurity G (R-Isomer) (CAS CATO-C4X-110989)
Recommended Standards
- N-[4-(Piperidine-1-sulfonyl)-phenyl]-succinamic acid (CAS 314764-11-9)
- Citalopram Nitrile Oxide (CAS 1346601-93-1)
- N-(1-Butyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-2-fluorobenzamide (CAS 941905-50-6)
- Citalopram EP Impurity B (Escitalopram EP Impurity B ) (CAS 411221-53-9)
- Bepotastine Impurity 10 (CAS CATO-C4X-183910)
- Nicardipine Hydrochloride EP Impurity C (CAS 21881-77-6)
- Furan Impuirty 1 (5-Butoxy-3-Methyl-2(5H)-Furanone) (CAS 119054-21-6)
- (4-(Tert-butyl)pyridin-2-yl)methanamine (CAS 608515-12-4)
- Ticagrelor Impurity 134 (CAS 2165881-71-8)
- 4-nitrobenzo[c][1,2,5]thiadiazole (CAS 6583-06-8)
- 4-Amino-n-(4,5-dihydro-1,3-thiazol-2-yl)benzene-1-sulfonamide (CAS 32365-02-9)
- 1-(4-Chlorophenyl)-2-((5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl)thio)ethan-1-one (CAS 302552-42-7)
- 2,7-Bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-5(4H)-one (CAS 1245806-65-8)
- Semaglutide impurity 40 (CAS CATO-C4X-222640)
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