Lisinopril Impurity N CAS 103300-91-0
| CAS No. | 103300-91-0 |
| Molecular Formula | C25H34F3N3O6 |
| Molecular Weight | 529.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Lisinopril Impurity N.
Lisinopril Impurity N (CAS 103300-91-0) is a certified pharmaceutical impurity reference standard with the molecular formula C25H34F3N3O6 and a molecular weight of 529.55 g/mol.
Lisinopril Impurity N (C25H34F3N3O6) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Lisinopril Impurity N meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H34F3N3O6 |
| Molecular Weight | 529.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Lisinopril Standards
- Lisinopril Impurity 26 (CAS 112246-14-7)
- Lisinopril Impurity 17 (CAS CATO-C4X-168117)
- Lisinopril Impurity 25 (CAS 199002-00-1)
- Lisinopril Impurity 27 (CAS CATO-C4X-168127)
- Lisinopril EP impurity I (CAS 927819-64-5)
- Lisinopril EP Impurity I (CAS CATO-C4X-16819)
- Lisinopril Impurity 13 (CAS CATO-C4X-168113)
- Lisinopril Impurity 14 (CAS CATO-C4X-168114)
Recommended Standards
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- 1-(p-Tolyl)but-3-en-1-yl acetate (CAS 71104-78-4)
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- 6-Hydroxy Warfarin-d5 (CAS 94820-64-1)
- Semaglutide Impurity 3 (CAS CATO-C4X-22263)
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