Lisinopril Impurity 26 CAS 112246-14-7
| CAS No. | 112246-14-7 |
| Molecular Formula | C25H34F3N3O6 |
| Molecular Weight | 529.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 529.55 g/mol gives Lisinopril Impurity 26 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Lisinopril Impurity 26 (CAS 112246-14-7, C25H34F3N3O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Lisinopril Impurity 26 (C25H34F3N3O6) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Lisinopril Impurity 26 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H34F3N3O6 |
| Molecular Weight | 529.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Lisinopril Standards
- Lisinopril Impurity N (CAS 103300-91-0)
- Lisinopril Impurity 17 (CAS CATO-C4X-168117)
- Lisinopril Impurity 25 (CAS 199002-00-1)
- Lisinopril Impurity 27 (CAS CATO-C4X-168127)
- Lisinopril EP impurity I (CAS 927819-64-5)
- Lisinopril EP Impurity I (CAS CATO-C4X-16819)
- Lisinopril Impurity 13 (CAS CATO-C4X-168113)
- Lisinopril Impurity 14 (CAS CATO-C4X-168114)
Recommended Standards
- Dabigatran Impurity 118 (CAS CATO-C4X-1089118)
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- Dabigatran Impurity 117 (CAS CATO-C4X-1089117)
- Carbomethoxyethylthioethyl 2-acetamido-2-deoxy-4-O-(β-D-galactopyranosyl)-β-D-glucopyranoside, 98% (CAS 87019-31-6)
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- 5-Chloro-1-(β-D-arabinofuranosyl)cytidine, 98% (CAS 17676-65-2)
- N-benzyl-2,6-bis(4-nitrophenyl)-N-phenyldinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine (CAS 1810078-07-9)
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