Sitagliptin Impurity 16 CAS 849832-73-1
| CAS No. | 849832-73-1 |
| Molecular Formula | C6H9F3N4O |
| Molecular Weight | 210.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 210.16 g/mol gives Sitagliptin Impurity 16 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Sitagliptin Impurity 16 (CAS 849832-73-1) is a certified pharmaceutical impurity reference standard with the molecular formula C6H9F3N4O and a molecular weight of 210.16 g/mol.
Owing to an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Sitagliptin Impurity 16 is typically white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 210.16 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Sitagliptin Impurity 16 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H9F3N4O |
| Molecular Weight | 210.16 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Sitagliptin Standards
- Sitagliptin impurity 11 (CAS 764667-63-2)
- Sitagliptin Impurity 117 (CAS 871035-61-9)
- Sitagliptin Impurity 125 (CAS 877402-45-4)
- Sitagliptin Impurity 81 (CAS 261952-27-6)
- Sitagliptin Impurity 109 (CAS 936630-56-7)
- Sitagliptin Impurity 166 (CAS 2226094-64-8)
- Sitagliptin Impurity 167 (CAS 1840966-95-1)
- Sitagliptin Impurity 17 (CAS 1036273-20-7)
Recommended Standards
- Sodium (Z)-1,4-diethoxy-1,4-dioxobut-2-en-2-olate (CAS 88330-76-1)
- Nebivolol Impurity 20 (CAS 105300-40-1)
- Foscarnet Sodium EP Impurity D (CAS 1474-78-8)
- Methyl 6-fluoro-3-oxo-3,3a-dihydro-2H-indazole-4-carboxylate (CAS 885522-84-9)
- Norepinephrine impurity 147 (CAS CATO-C4X-1514147)
- Cefminox Impurity 7 (CAS CATO-C4X-19267)
- Avibactam impurity 98 (CAS CATO-C4X-134898)
- 4-Bromo-N-(4-bromobenzyl)benzamide (CAS 670229-48-8)
- (2R,6S)-rel-1,2,6-Trimethylpiperazine dihydrochloride (CAS 1195782-28-5)
- 1-((2-Methoxy-4,5-dimethylphenyl)sulfonyl)-1H-pyrazole (CAS 1206087-13-9)
- Methylbenzenesulfonic acid (2E)-2-(2,2,2-trifluoroethylidene)hydrazide (CAS 888071-59-8)
- Mal-PEG2-C2-Boc (CAS 1374666-31-5)
- (R)-2-(1,3-Dioxoisoindolin-2-yloxy)-4-methylpentanoic acid (CAS 310404-45-6)
- Semaglutide impurity 29 (CAS CATO-C4X-222629)
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