Sitagliptin Impurity 166 CAS 2226094-64-8
| CAS No. | 2226094-64-8 |
| Molecular Formula | C10H7F3O2 |
| Molecular Weight | 216.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Sitagliptin Impurity 166 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
CATO supplies Sitagliptin Impurity 166 (CAS 2226094-64-8), a pharmacopoeial impurity reference standard (molecular formula C10H7F3O2, MW 216.16 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Sitagliptin Impurity 166 (C10H7F3O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C10H7F3O2 |
| Molecular Weight | 216.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
Related Sitagliptin Standards
- Sitagliptin Impurity 167 (CAS 1840966-95-1)
- Sitagliptin Impurity 109 (CAS 936630-56-7)
- Sitagliptin Impurity 147 (CAS 1481965-39-2)
- Sitagliptin Impurity 118 (CAS 1261633-32-2)
- Sitagliptin Impurity 78 (Nitroso-STG-19) (NTTP) (CAS 2892260-32-9)
- Sitagliptin impurity 11 (CAS 764667-63-2)
- Sitagliptin Impurity 16 (CAS 849832-73-1)
- Sitagliptin Impurity 58 (CAS 667-35-6)
Recommended Standards
- Cinacalcet Impurity 46 (CAS 2062-25-1)
- Cinacalcet Impurity 45 (CAS 16642-92-5)
- L-threo-Droxidopa-13C2,15N (CAS 1276295-04-5)
- Cinacalcet Impurity 38 (CAS 67801-07-4)
- Vortioxetine Impurity 40 (CAS CATO-C4X-105640)
- Fosfomycin Impurity 72 (CAS 26017-01-6)
- Aztreonam impurity 66 (CAS CATO-C4X-152266)
- Avatrombopag Impurity 78 (CAS CATO-C4X-223478)
- 3-Chloro-5-methoxybenzo[b]thiophene-2-carbaldehyde (CAS 1315550-50-5)
- Ethyl N-(2,4-dichloro-5-methoxyphenyl)-N-((4-fluorophenyl)sulfonyl)glycinate (CAS 338961-58-3)
- (R)-1-(5-fluoro-3-(1H-pyrazol-1-yl)pyridin-2-yl)ethan-1-ol (CAS 2435611-72-4)
- 1-[2-(Trifluoromethyl)phenyl]imidazo[1,5-a]pyridine-3-carboxylic acid (CAS 2059993-43-8)
- 2-Bromo-5-(bromomethyl)thiophene (CAS 59311-27-2)
- Semaglutide impurity 29 (CAS 1188328-22-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com