Sitagliptin Impurity 167 CAS 1840966-95-1
| CAS No. | 1840966-95-1 |
| Molecular Formula | C10H7F3O2 |
| Molecular Weight | 216.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Sitagliptin Impurity 167 (C10H7F3O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Sitagliptin Impurity 167 (CAS 1840966-95-1, C10H7F3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Sitagliptin Impurity 167 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H7F3O2 |
| Molecular Weight | 216.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
Related Sitagliptin Standards
- Sitagliptin Impurity 166 (CAS 2226094-64-8)
- Sitagliptin Impurity 109 (CAS 936630-56-7)
- Sitagliptin Impurity 147 (CAS 1481965-39-2)
- Sitagliptin Impurity 118 (CAS 1261633-32-2)
- Sitagliptin Impurity 78 (Nitroso-STG-19) (NTTP) (CAS 2892260-32-9)
- Sitagliptin impurity 11 (CAS 764667-63-2)
- Sitagliptin Impurity 16 (CAS 849832-73-1)
- Sitagliptin Impurity 58 (CAS 667-35-6)
Recommended Standards
- L-threo-Droxidopa-13C2,15N (CAS 1276295-04-5)
- Cinacalcet Impurity 46 (CAS 2062-25-1)
- 1-(2,4-Dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1-(2-fluoroethyl)urea (CAS 500315-80-0)
- Cinacalcet Impurity 45 (CAS 16642-92-5)
- Roflumilast Impurity 62 Formate (CAS CATO-C4X-193566)
- Ciprofloxacin impurity 43 (CAS 105093-21-8)
- Citalopram EP Impurity B Oxalate (CAS 1332724-03-4)
- tert-Butyl 2-(3,5-dimethoxyphenyl)piperazine-1-carboxylate (CAS 886769-89-7)
- (2-((Trimethylsilyl)ethynyl)pyridin-4-yl)methanol (CAS 2380302-07-6)
- 2-(Bromomethyl)-6-chloro-3-(trifluoromethyl)pyridine (CAS 1807215-61-7)
- 3-(4-Methoxybenzoyl)phenyl acetate (CAS 108897-14-9)
- 4-Chloro-1-phenethyl-1h-pyrazol-3-amine (CAS 1343262-82-7)
- n-(Cyclopropylmethyl)-3-ethynylaniline (CAS 1156170-44-3)
- Semaglutide impurity 277 (CAS CATO-C4X-2226277)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com