Montelukast Impurity 50 CAS 1044705-96-5
| CAS No. | 1044705-96-5 |
| Molecular Formula | C37H40ClNO3S |
| Molecular Weight | 614.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 614.24 g/mol gives Montelukast Impurity 50 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Montelukast Impurity 50 (CAS 1044705-96-5) is a certified pharmaceutical impurity reference standard with the molecular formula C37H40ClNO3S and a molecular weight of 614.24 g/mol.
The molecular framework of Montelukast Impurity 50 (C37H40ClNO3S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Montelukast Impurity 50 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C37H40ClNO3S |
| Molecular Weight | 614.24 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Montelukast Standards
- Montelukast Acid Impurity Disodium Salt (CAS 213380-27-9)
- Montelukast Sulfone (CAS 2714018-24-1)
- Montelukast Impurity 22 (CAS 1266620-74-9)
- Montelukast Impurity 9 (CAS CATO-C4X-10319)
- Montelukast Impurity 8 (CAS CATO-C4X-10318)
- Montelukast Sodium EP Impurity G (CAS 1428448-96-7)
- cis-Montelukast Sulfoxide (CAS 1428511-42-5)
- Montelukast R-Sulfoxide (CAS 1152185-58-4)
Recommended Standards
- TAE 684 (CAS 761439-42-3)
- 3-Chloro-2-{2-[(1E,3E)-2-(4-chlorobenzenesulfonyl)-3-{[(2,6-dichlorophenyl)methoxy]imino}prop-1-en-1-yl]hydrazin-1-yl}-5-(trifluoromethyl)pyridine (CAS 338407-65-1)
- 1H,1H,2H,2H-Perfluoro(11-methyldodecan-1-ol) (CAS 194427-39-9)
- Bromfenac Impurity 2 (CAS CATO-C4X-20022)
- Thioridazine Impurity 1 (CAS 7643-08-5)
- Midazolam Impurity 29 (CAS CATO-C4X-150929)
- Cinitapride Impurity N12 (CAS 64730-01-4)
- 3-(((Benzyloxy)carbonyl)amino)-2-hydroxy-2-methylpropanoic acid (CAS 1488182-93-9)
- 1H-Indazole-3-thiol (CAS 27006-38-8)
- 6-Methyl-4-[(4-methylphenyl)sulfonyl]-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid (CAS 1858242-10-0)
- Enzalutamide Impurity 69 (CAS 2088914-58-1)
- (2E)-3-(4-Isopropoxyphenyl)acrylic acid (CAS 586960-22-7)
- n-((1-Ethylpyrrolidin-2-yl)methyl)-3-methylcyclopentan-1-amine (CAS 1339377-21-7)
- Liraglutide Impurity 30 (CAS CATO-C4X-199230)
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