Doxycycline Hydrochloride CAS 10592-13-9
| CAS No. | 10592-13-9 |
| Molecular Formula | C22H24N2O8 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Doxycycline Hydrochloride (CAS 10592-13-9), molecular formula C22H24N2O8HCl and molecular weight 480.90 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Doxycycline Hydrochloride (C22H24N2O8HCl) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Doxycycline Hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H24N2O8 HCl |
| Molecular Weight | 480.90 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1960 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Doxycycline Standards
- Doxycycline EP Impurity F (CAS 122861-53-4)
- Doxycycline Monohydrate (CAS 17086-28-1)
- Doxycycline-13CD3 (CAS 1902958-13-7)
- Doxycycline Impurity 20 (CAS 2000233-92-9)
- Doxycycline Hyclate (CAS 24390-14-5)
- Doxycycline-d3 (CAS 2747918-45-0)
- Doxycycline-d3 HCl (CAS 2747918-45-0 (free base))
- Doxycycline EP Impurity A (CAS 3219-99-6)
Recommended Standards
- Methyl 3-(oxolan-2-yl)propanoate (CAS 69248-88-0)
- 1-(4-Chlorobenzyl)-5-methylindoline-2,3-dione (CAS 303998-01-8)
- (6-Bromo-3-(trifluoromethyl)pyridin-2-yl)methanol (CAS 1806983-20-9)
- 1-(3,5-Dimethyl-4-propoxyphenyl)ethanone (CAS 1119425-75-0)
- (S)-2-(1-Aminoethyl)phenol (CAS 133511-37-2)
- 7-Hydroxy-2H-benzo[b][1,4]oxazin-3(4H)-one (CAS 67193-97-9)
- (2,6-Dimethoxyphenyl)(quinolin-3-yl)methanone (CAS 1187163-88-7)
- 3-(Aminomethyl)-5-chloro-6-(difluoromethyl)pyridin-2-amine (CAS 1804699-31-7)
- 1-methyl-2-pentyl-2H-pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione (CAS 866010-14-2)
- Angiotensin III Antipeptide (CAS 133605-55-7)
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