Doxycycline Impurity 20 CAS 2000233-92-9
| CAS No. | 2000233-92-9 |
| Molecular Formula | C22H20N2O7 |
| Molecular Weight | 424.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Doxycycline Impurity 20 (C22H20N2O7) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Doxycycline Impurity 20 (CAS 2000233-92-9, C22H20N2O7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Doxycycline Impurity 20 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H20N2O7 |
| Molecular Weight | 424.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Nitrogen Atoms | 2 |
Related Doxycycline Standards
- Doxycycline EP Impurity B (CAS CATO-C4X-19312)
- Doxycycline Impurity 21 (CAS CATO-C4X-193121)
- Doxycycline EP Impurity F (CAS 122861-53-4)
- Doxycycline EP Impurity A (CAS 3219-99-6)
- Doxycycline EP Impurity C (CAS 6543-77-7)
- Doxycycline EP Impurity D (CAS 97583-08-9)
- Doxycycline Impurity 8 (CAS CATO-C4X-19318)
- Doxycycline (CAS 564-25-0)
Recommended Standards
- 87592-77-6 C20H24O10 Smyrindioloside W1282 (CAS 87592-77-6)
- Glucosamine Sulfate Impurity 5 (CAS 35061-50-8)
- 86940-46-7 Praeroside II (CAS 86940-46-7)
- Phytomenadione/Vitamin K1 Impurity 123 (CAS CATO-C4X-2207123)
- Imatinib Impurity 98 (CAS CATO-C4X-106898)
- Fluorescein Impurity 3 (CAS 1428447-91-9)
- Eldecalcitol Impurity 39 (CAS CATO-C4X-214039)
- 1-(5,5-Dimethyl-4,5-dihydro-1,3-thiazol-2-yl)piperazine dihydrochloride (CAS 1334148-37-6)
- 1-(iodomethyl)-4-methyl-2-oxabicyclo[2.1.1]hexane (CAS 2167041-68-9)
- 4-Amino-3-fluoro-2-(trifluoromethyl)benzoic acid (CAS 1805074-76-3)
- 1-Bromo-2-chloro-5-fluoro-3-methylbenzene (CAS 1000576-68-0)
- 6-Acetyl-7-fluoro-2H-benzo[b][1,4]oxazin-3(4H)-one (CAS 1613720-26-5)
- Hydrochlorothiazide Impurity 6 (CAS 23141-82-4)
- Tirzepatide Impurity 10 (CAS CATO-C4X-324010)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com