Isavuconazole Impurity 221 CAS 1062201-83-5
| CAS No. | 1062201-83-5 |
| Molecular Formula | C12H11F2N3O |
| Molecular Weight | 251.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Isavuconazole Impurity 221 (C12H11F2N3O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies Isavuconazole Impurity 221 (CAS 1062201-83-5), a pharmacopoeial impurity reference standard (molecular formula C12H11F2N3O, MW 251.23 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Isavuconazole Impurity 221 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H11F2N3O |
| Molecular Weight | 251.23 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Isavuconazole Standards
- Isavuconazole Impurity 103 (CAS CATO-C4X-1236103)
- Isavuconazole Impurity 104 (CAS 2922040-42-2)
- Isavuconazole Impurity 105 (CAS CATO-C4X-1236105)
- Isavuconazole Impurity 129 (CAS 2122222-15-3)
- Isavuconazole impurity 71 (CAS CATO-C4X-1236171)
- Isavuconazole Impurity 195 (CAS CATO-C4X-1236195)
- Isavuconazole Impurity 43 (CAS CATO-C4X-123643)
- Isavuconazole Impurity 222 (CAS CATO-C4X-1236222)
Recommended Standards
- Efinaconazole Impurity 14 (CAS 135270-10-9)
- Efinaconazole Impurity 15 (CAS 135270-07-4)
- Efinaconazole Impurity 16 (CAS CATO-C4X-124316)
- Efinaconazole Impurity 21 (CAS CATO-C4X-124321)
- Sitagliptin Impurity 15 (CAS 1217809-78-3)
- Cloxacillin EP Impurity D (CAS 23598-72-3)
- Sitagliptin Impurity 54 (CAS 1608491-98-0（free base）)
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- PACAP-Related Peptide (PRP), rat (CAS 132769-35-8)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com