Cloxacillin EP Impurity D CAS 23598-72-3
| CAS No. | 23598-72-3 |
| Molecular Formula | C11H8ClNO3 |
| Molecular Weight | 237.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Cloxacillin EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Cloxacillin EP Impurity D (CAS 23598-72-3, C11H8ClNO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Cloxacillin EP Impurity D is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 237.64 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C11H8ClNO3 |
| Molecular Weight | 237.64 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Cloxacillin Standards
- Cloxacillin Impurity 23 (CAS CATO-C4X-159723)
- Cloxacillin Impurity 27 (CAS CATO-C4X-159727)
- Cloxacillin Impurity 26 (CAS CATO-C4X-159726)
- Cloxacillin Impurity 16 (CAS 1143-82-4)
- Cloxacillin Impurity N1 (CAS 4357-94-2)
- Cloxacillin Impurity 15 (CAS 1598387-74-6)
- Cloxacillin Impurity 17 (CAS 91059-01-7)
- Cloxacillin Impurity 18 (CAS 25629-50-9)
Recommended Standards
- Lenvatinib Impurity 35 (CAS 771464-30-3)
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- Macitentan Impurity 8 (CAS 38353-06-9)
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- Ethyl 2-amino-5-bromobenzoate (CAS 63243-76-5)
- Calcitonin N-Terminal Flanking Peptide (human) (CAS 118277-01-3)
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