Iloperidone Impurity 10 CAS 106266-04-0
| CAS No. | 106266-04-0 |
| Molecular Formula | C12H13F2NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Iloperidone Impurity 10 (C12H13F2NOHCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Iloperidone Impurity 10 (CAS 106266-04-0, C12H13F2NOHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H13F2NO HCl |
| Molecular Weight | 261.70 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Iloperidone Standards
- Iloperidone-d3 (CAS 1071167-49-1)
- Iloperidone-d3 (CAS 1071168-82-5)
- Iloperidone Impurity 31 (CAS 116218-80-5)
- Iloperidone Impurity 8 (CAS 1209459-88-0)
- Iloperidone Impurity N1 (CAS 133454-47-4)
- Iloperidone Hydroxy Impurity (CAS 133454-55-4)
- Iloperidone Impurity 4 (CAS 133455-04-6)
- Iloperidone N-Oxide (CAS 1375651-09-4)
Recommended Standards
- Niraparib impurity 24 (CAS CATO-C4X-232924)
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- Difamilast Impurity 3 (CAS 937782-02-0)
- 5'-O-TBDMS-dA (CAS 51549-30-5)
- 6-Hydroxy-8-(4-(4-(5-hydroxypyrimidin-2-yl)piperazin-1-yl)butyl)-8-azaspiro[4.5]decane-7,9-dione (CAS 125481-59-6)
- 8-Piperazin-1-yl-2h-[1,2,4]triazolo[4,3-a]pyrazin-3-one (CAS 1544881-78-8)
- 2-(4-Bromophenyl)azepane (CAS 383129-24-6)
- Methyl (S)-5-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-((1,1,1-trifluoropropan-2-yl)oxy)benzoate (CAS 2639835-82-6)
- 2-Amino-4-(chloromethyl)pyridine Hydrochloride (CAS 1186663-31-9)
- Glucagon (1-29) (CAS 16941-32-5)
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