Difamilast Impurity 3 CAS 937782-02-0
| CAS No. | 937782-02-0 |
| Molecular Formula | C22H22F2N2O5 |
| Molecular Weight | 432.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Difamilast Impurity 3 (CAS 937782-02-0), a pharmacopoeial impurity reference standard (molecular formula C22H22F2N2O5, MW 432.42 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Difamilast Impurity 3 (C22H22F2N2O5) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Difamilast Impurity 3 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H22F2N2O5 |
| Molecular Weight | 432.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difamilast Standards
- Difamilast Impurity 5 (CAS 2103190-81-2)
- Difamilast Impurity 8 (CAS 2103190-85-6)
- Difamilast Impurity 1 (CAS 1574285-40-7)
- Difamilast (CAS 937782-05-3)
- Difamilast Impurity 10 (CAS 2103190-58-3)
- Difamilast Impurity 6 (CAS 937782-01-9)
- Difamilast Impurity 2 (CAS 2103190-94-7)
- Difamilast Impurity 4 (CAS 2103190-65-2)
Recommended Standards
- Nimodipine impurity 43 (CAS CATO-C4X-138543)
- 3,5,6,7,8,3',4'-Heptamethoxyflavone (CAS 1178-24-1)
- Naphthofluorescein (CAS 61419-02-1)
- Fmoc-(S)-3-Amino-3-(2-nitro-phenyl)-propionic acid (CAS 507472-25-5)
- Indometacin Impurity 58 (CAS CATO-C4X-147058)
- Azathioprine Impurity 9 (CAS 1190008-04-8)
- Docetaxel Impurity 47 (CAS 1144034-42-3)
- 2-fluoro-5-(1H-1,2,3,4-tetrazol-1-yl)aniline (CAS 924871-22-7)
- 2-(4-Chlorobenzoyl)-5-methoxy-3-methyl-1-benzofuran (CAS 303145-45-1)
- 6-Bromo-2-(pyridin-4-yl)quinoline-4-carbonyl chloride (CAS 1203419-34-4)
- (S)-α-Methyl 4-Trifluoromethoxyphenylalaine, 97% (CAS 1269926-90-0)
- Ethyl 4-chloro-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carboxylate (CAS 427878-41-9)
- 2-Chloro-5-(3-nitrophenyl)-1,3,4-thiadiazole (CAS 88541-06-4)
- Semaglutide impurity 195 (CAS CATO-C4X-2226195)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com