Orforglipron impurity 36 CAS 1092961-07-3
| CAS No. | 1092961-07-3 |
| Molecular Formula | C8H7FN2 |
| Molecular Weight | 150.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Orforglipron impurity 36 (CAS 1092961-07-3) is a certified pharmaceutical impurity reference standard with the molecular formula C8H7FN2 and a molecular weight of 150.15 g/mol.
Structurally, Orforglipron impurity 36 (C8H7FN2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 150.15 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C8H7FN2 |
| Molecular Weight | 150.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Orforglipron Standards
- Orforglipron impurity 121 (CAS 2212021-39-9)
- Orforglipron Impurity 113 (CAS CATO-C4X-3234113)
- Orforglipron Impurity 43 (CAS 2025595-61-1(free base))
- Orforglipron impurity 25 (CAS 443-86-7)
- Orforglipron Impurity 63 (CAS 2212021-57-1)
- Orforglipron Impurity 115 (CAS CATO-C4X-3234115)
- Orforglipron impurity 28 (CAS 35270-87-2)
- Orforglipron impurity 27 (CAS 465529-57-1)
Recommended Standards
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- Nepafenac Impurity 1 (CAS 2835-77-0)
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- Decyl β-D-glucopyranoside [for Biochemical Research] (CAS 58846-77-8)
- Propargyl-PEG4-tetra-Ac-beta-D-galactose (CAS 1397682-61-9)
- 1-(3-Bromo-5-fluorophenyl)-2-methylpropan-2-amine (CAS 1539067-46-3)
- Tert-butyl bis((3-fluoropyridin-2-yl)methyl)carbamate (CAS 1346447-11-7)
- Ethyl 4-((pyridin-2-ylmethyl)amino)butanoate (CAS 1342874-11-6)
- Hepcidin/LEAP-1 (Human); Liver-Expressed Antimicrobial Peptide (CAS 342790-21-0)
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