Orforglipron impurity 121 CAS 2212021-39-9
| CAS No. | 2212021-39-9 |
| Molecular Formula | C8H11FN2 |
| Molecular Weight | 154.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Orforglipron impurity 121 (C8H11FN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Orforglipron impurity 121 (CAS 2212021-39-9, C8H11FN2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H11FN2 |
| Molecular Weight | 154.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Orforglipron Standards
- Orforglipron impurity 36 (CAS 1092961-07-3)
- Orforglipron Impurity 113 (CAS CATO-C4X-3234113)
- Orforglipron Impurity 43 (CAS 2025595-61-1(free base))
- Orforglipron impurity 25 (CAS 443-86-7)
- Orforglipron Impurity 63 (CAS 2212021-57-1)
- Orforglipron Impurity 115 (CAS CATO-C4X-3234115)
- Orforglipron impurity 28 (CAS 35270-87-2)
- Orforglipron impurity 27 (CAS 465529-57-1)
Recommended Standards
- Policresulen Impurity 16 (CAS 17011-26-6)
- Diethyl Sulfate (CAS 64-67-5)
- Busulfan Impurity 3 (CAS 26978-64-3)
- 2-Amino-4H-cyclopenta[d]thiazol-6(5H)-one (CAS 1026710-03-1)
- Cefmetazole Impurity 11 (CAS 55817-29-3)
- Vonoprazan Impurity 43 (CAS 2169271-28-5)
- Erlotinib Impurity 54 (CAS CATO-C4X-106954)
- 1-Ethyl-6-(pyrrolidin-1-ylsulfonyl)benzo[cd]indol-2(1H)-one (CAS 304685-40-3)
- 2,6-Naphthalenedisulfonyl Dichloride (CAS 13827-62-8)
- Formoterol impurity 131 (CAS 2386293-34-9（free base）)
- 5-Bromo-2-chloro-N-(2-(5-(1-hydroxyethyl)thiophen-2-yl)ethyl)benzamide (CAS 2034256-43-2)
- 1-Ethyl-3-methyl-1H-pyrazole-5-carbonyl isothiocyanate (CAS 1489546-98-6)
- 4-(4-bromophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-5,6-dihydrobenzo[h]quinazoline (CAS 956965-83-6)
- DAPK Substrate Peptide (CAS 386769-53-5)
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