Atorvastatin EP Impurity E(Calcium salt) CAS 1105067-88-6
| CAS No. | 1105067-88-6 |
| Molecular Formula | 2*C33H34FN2O5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Atorvastatin EP Impurity E(Calcium salt).
As a process- or degradation-related impurity, Atorvastatin EP Impurity E(Calcium salt) (CAS 1105067-88-6, C33H34FN2O5Ca) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Atorvastatin EP Impurity E(Calcium salt) (C33H34FN2O5Ca) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 17.5, corresponding to approximately 17 ring(s) or double-bond equivalent(s). With a molecular weight of 597.72 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Atorvastatin EP Impurity E(Calcium salt) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | 2*C33H34FN2O5 Ca |
| Molecular Weight | 597.72 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Atorvastatin Standards
- Atorvastatin Impurity 22 (CAS 1035205-25-4)
- Atorvastatin Calcium Propylene Glycol Solvate (CAS 1040350-07-9)
- Atorvastatin Lactone Diepoxide (CAS 1046118-40-4)
- Atorvastatin Lactam calcium Salt Impurity (CAS 1046118-41-5)
- Atorvastatin Impurity 86 (CAS 1046118-44-8)
- Atorvastatin Impurity 141 Calcium Salt (CAS 1046378-58-8)
- Atorvastatin Impurity 76 (CAS 1099474-28-8)
- Atorvastatin EP Impurity F(Calcium Salt) (CAS 1105067-87-5)
Recommended Standards
- Aripiprazole Impurity 12 (CAS 52749-50-5)
- Minodronic Impurity 2 (CAS 19741-30-1)
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- 2-(2-methoxypyrimidin-4-yl)ethan-1-ol (CAS 1240725-45-4)
- methyl ester N-(6,8-difluoro-2H-1-benzopyran-3-yl)-carbamic acid (CAS 1034001-13-2)
- 6-Chloropurine, Hydrochloride (CAS 88166-54-5)
- (3S)-3-amino-3-(3-fluorofuran-2-yl)propanoic acid (CAS 1366442-62-7)
- tert-Butyl 3-bromo-6,7-dihydro-5H-spiro[imidazo[1,2-a]pyrazine-8,4'-piperidine]-1'-carboxylate (CAS 1251013-34-9)
- 7-Methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidine-6-sulfonyl chloride (CAS 893632-89-8)
- Acetyl tetrapeptide-9(Dermican LS 9837) (CAS 928006-50-2)
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