Atorvastatin Impurity 141 Calcium Salt CAS 1046378-58-8

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.1046378-58-8
Molecular Formula2*C33H32FN2O6
Molecular WeightN/A
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Atorvastatin Impurity 141 Calcium Salt CAS 1046378-58-8 chemical structure

Description

The occurrence of Atorvastatin Impurity 141 Calcium Salt is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

CATO supplies Atorvastatin Impurity 141 Calcium Salt (CAS 1046378-58-8), a pharmacopoeial impurity reference standard (molecular formula C33H32FN2O6Ca, MW 611.70 g/mol) used for the identification and quantification of trace impurities in APIs.

Structurally, Atorvastatin Impurity 141 Calcium Salt (C33H32FN2O6Ca) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 18.5, corresponding to approximately 18 ring(s) or double-bond equivalent(s). With a molecular weight of 611.70 g/mol, it falls into the high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

As a certified reference material (CRM), Atorvastatin Impurity 141 Calcium Salt meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular Formula2*C33H32FN2O6 Ca
Molecular Weight611.70 g/mol
Purity97%+
StorageStore in a cool place (≤25°C), protect from light, keep sealed and dry
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)18.5
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1988
Halogen ContentF-containing
Nitrogen Atoms2

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