Atorvastatin Impurity 86 CAS 1046118-44-8
| CAS No. | 1046118-44-8 |
| Molecular Formula | C26H24FNO5 |
| Molecular Weight | 449.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Atorvastatin Impurity 86 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Atorvastatin Impurity 86 (CAS 1046118-44-8) is a certified pharmaceutical impurity reference standard with the molecular formula C26H24FNO5 and a molecular weight of 449.47 g/mol.
Structurally, Atorvastatin Impurity 86 (C26H24FNO5) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 449.47 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Atorvastatin Impurity 86 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H24FNO5 |
| Molecular Weight | 449.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Atorvastatin Standards
- Atorvastatin Calcium EP Impurity D (CAS 873950-19-7)
- Atorvastatin Impurity 99 (CAS CATO-C4X-113299)
- Atorvastatin Impurity 27 (CAS 693793-82-7)
- Atorvastatin EP Impurity D (CAS 148146-51-4)
- Atorvastatin Impurity 77 (CAS 2299304-89-3)
- Atorvastatin Impurity 103 (CAS 1797905-42-0)
- Atorvastatin Oxirane Impurity (CAS 1246818-88-1)
- Atorvastatin Impurity 82 (CAS 125971-96-2)
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- 2-Amino-2,4-difluoroacetophenone (CAS 643029-92-9)
- Endo-38a-Pro-Exenatide trifluoroacetate salt (CAS 1678416-95-9)
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