Levofloxacin Impurity 82 CAS 110548-03-3
| CAS No. | 110548-03-3 |
| Molecular Formula | C15H14F3NO4 |
| Molecular Weight | 329.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Levofloxacin Impurity 82.
As a process- or degradation-related impurity, Levofloxacin Impurity 82 (CAS 110548-03-3, C15H14F3NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Levofloxacin Impurity 82 (C15H14F3NO4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Levofloxacin Impurity 82 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H14F3NO4 |
| Molecular Weight | 329.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Levofloxacin Standards
- Levofloxacin Impurity 31 (CAS CATO-C4X-137131)
- Levofloxacin impurity 67 (CAS CATO-C4X-137167)
- Levofloxacin EP Impurity G(Levofloxacin USP Related Compound E) (CAS 151250-76-9)
- Levofloxacin Impurity 61 (CAS CATO-C4X-137161)
- Levofloxacin Impurity 89 (CAS CATO-C4X-137189)
- Levofloxacin Impurity 21 (CAS 1797510-34-9)
- Levofloxacin Impurity 44 (CAS 94714-58-6)
- Levofloxacin impurity 01 (CAS 154228-18-9)
Recommended Standards
- Moxifloxacin impurity 199 (CAS CATO-C4X-1074199)
- 5-(1,3-Dimethyl-1h-pyrazol-4-yl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylic acid (CAS 1005560-38-2)
- Methyl 2-(4-(2-methyl-3-(trifluoromethyl)phenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)propanoate (CAS 2197054-56-9)
- 6-Fluoro-1-(2-hydroxyethyl)-4-oxo-7-(pyridin-4-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid (CAS 109034-04-0)
- Thiamine Impurity 58 (CAS CATO-C4X-187358)
- Trimebutine Impurity 17 (CAS CATO-C4X-185817)
- Suzetrigine Impurity 53 (CAS CATO-C4X-336953)
- 2-({4-[4-nitro-3-(trifluoromethyl)phenyl]piperazin-1-yl}methyl)-3,4-dihydroquinazolin-4-one (CAS 930060-26-7)
- (R)-2-(((Benzyloxy)carbonyl)amino)-3-(4-(tert-butyl)phenyl)propanoic acid (CAS 1270290-73-7)
- Methyl 3-methoxy-5-(4-methoxyphenyl)benzoate (CAS 1820647-87-7)
- Aconitane-7,8-diol, 20-ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]-, [1α,4(S),6β,14α,16β]-, 2-hydroxy-1,2,3-propanetricarboxylate (salt) (9CI) (CAS 112825-05-5)
- Letrozole Impurity 12 (CAS CATO-C4X-182912)
- 4-(4-Morpholinophenyl)butanoic acid (CAS 59826-58-3)
- Semaglutide impurity 257 (CAS CATO-C4X-2226257)
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