Levofloxacin impurity 67 CAS CATO-C4X-137167
| CAS No. | CATO-C4X-137167 |
| Molecular Formula | C15H14FN3O5 |
| Molecular Weight | 335.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Levofloxacin impurity 67.
Levofloxacin impurity 67 (CAS CATO-C4X-137167) is a certified pharmaceutical impurity reference standard with the molecular formula C15H14FN3O5 and a molecular weight of 335.29 g/mol.
Structurally, Levofloxacin impurity 67 (C15H14FN3O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 335.29 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H14FN3O5 |
| Molecular Weight | 335.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Levofloxacin Standards
- Levofloxacin EP Impurity G(Levofloxacin USP Related Compound E) (CAS 151250-76-9)
- Levofloxacin Impurity 61 (CAS CATO-C4X-137161)
- Levofloxacin Impurity 89 (CAS CATO-C4X-137189)
- Levofloxacin Impurity 31 (CAS CATO-C4X-137131)
- Levofloxacin Impurity 82 (CAS 110548-03-3)
- Levofloxacin Impurity 30 (CAS CATO-C4X-137130)
- Levofloxacin Impurity 22 (CAS 82419-46-3)
- Levofloxacin EP Impurity B (CAS 117707-40-1)
Recommended Standards
- N-(4,6-Difluorobenzo[d]thiazol-2-yl)-4-nitrobenzamide (CAS 313520-81-9)
- Ethyl 2-(ethylthio)-7-oxo-5-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate (CAS 1263216-49-4)
- Ethyl phenyl 4-nitrophenethylphosphonate (CAS 3384-91-6)
- (R)-2-(((BENZYLOXY)CARBONYL)AMINO)-3-(2,4-DIFLUOROPHENYL)PROPANOIC ACID (CAS 1270296-27-9)
- Carbetocin Impurity 16 (CAS CATO-C4X-191116)
- Pitavastatin Impurity 35 (CAS CATO-C4X-103735)
- Ertapenem Impurity 66 (CAS CATO-C4X-163366)
- 1-Iodo-2-methoxy-3-nitrobenzene (CAS 211943-70-3)
- [6-chloro-4-(trifluoromethyl)pyridin-2-yl]methanol (CAS 1421961-60-5)
- 2-{dimethyl-[1,2,3,4]tetrazolo[1,5-a]pyrimidin-6-yl}acetic acid (CAS 1016708-53-4)
- 4-Bromo-2-methylbenzylamine (CAS 376646-62-7)
- 3-(4-(tert-Butoxycarbonyl)-2-methylpiperazin-1-yl)propanoic acid (CAS 1060813-93-5)
- 1-(2,2-Difluoroethyl)-3,5-dimethyl-1H-pyrazole-4-carbaldehyde (CAS 1006487-12-2)
- (Des-Thr7)-Glucagon trifluoroacetate salt (CAS 1802078-28-9)
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