Esomeprazole Impurity 31 CAS 1114596-75-6
| CAS No. | 1114596-75-6 |
| Molecular Formula | C8H10ClNO |
| Molecular Weight | 171.62 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Esomeprazole Impurity 31 (CAS 1114596-75-6, C8H10ClNO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C8H10ClNO, Esomeprazole Impurity 31 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 171.62 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H10ClNO |
| Molecular Weight | 171.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Esomeprazole Standards
- Esomeprazole Impurity 113 (CAS 220771-03-9)
- Esomeprazole Impurity 28 (CAS 577-72-0)
- Esomeprazole Impurity 44 (CAS 16133-49-6)
- Esomeprazole Impurity 66 (CAS 14248-66-9)
- Esomeprazole Impurity 105 (CAS 86604-78-6)
- Esomeprazole Impurity 115 (CAS 1424857-83-9)
- Esomeprazole Impurity 40 (CAS 86604-80-0)
- Esomeprazole Impurity 39 (CAS 92806-98-9)
Recommended Standards
- 3-Chloro-4-methoxy-benzylamine (CAS 115514-77-7)
- 2-(dimethylamino)-3,4,5-trimethoxybenzoic acid 2-phenylbutyl ester 2-phenylbutyl 2-(dimethylamino)-3,4,5-trimethoxy-benzoate 6068-72-0 A832843 (CAS 6068-72-0)
- Ilaprazole Impurity 72 (CAS 1256807-19-8)
- 30427-11-3 5-Chloro-2-methoxy-N-methylaniline MFCD11152449 (CAS 30427-11-3)
- Obeticholic Acid Impurity 9 (CAS CATO-C4X-11539)
- Tamsulosin Impurity 22 HCl (CAS 50505-66-3)
- Atrasentan Impurity 156 (CAS 1059040-11-7)
- 1-(3-Chloro-2-fluorophenyl)pentan-1-amine (CAS 1270509-26-6)
- 2-Cyclopropyl-5-fluoropyrimidine-4,6-diol (CAS 617715-97-6)
- 2-(4-Fluorophenyl)-N-((1-methyl-1H-pyrrol-2-yl)methyl)ethan-1-amine (CAS 774555-28-1)
- 2-Fluoro-5-(pyridin-3-yl)benzaldehyde (CAS 1178350-70-3)
- (2,4-Dichlorobenzyl)(1-phenylethyl)amine (CAS 356531-87-8)
- 2-Methylanthraquinone (CAS 84-54-8)
- Insulin Degludec Impurity 15 (CAS CATO-C4X-215715)
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