Esomeprazole Impurity 44 CAS 16133-49-6
| CAS No. | 16133-49-6 |
| Molecular Formula | C7H8N2O3 |
| Molecular Weight | 168.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Esomeprazole Impurity 44.
Esomeprazole Impurity 44 (CAS 16133-49-6) is a certified pharmaceutical impurity reference standard with the molecular formula C7H8N2O3 and a molecular weight of 168.15 g/mol.
Owing to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage, Esomeprazole Impurity 44 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 168.15 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Esomeprazole Impurity 44 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H8N2O3 |
| Molecular Weight | 168.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Nitrogen Atoms | 2 |
Related Esomeprazole Standards
- Esomeprazole Impurity 28 (CAS 577-72-0)
- Esomeprazole Impurity 66 (CAS 14248-66-9)
- Esomeprazole Impurity 105 (CAS 86604-78-6)
- Esomeprazole Impurity 115 (CAS 1424857-83-9)
- Esomeprazole Impurity 40 (CAS 86604-80-0)
- Esomeprazole Impurity 39 (CAS 92806-98-9)
- Esomeprazole Impurity 97 (CAS 142885-88-9)
- Esomeprazole Impurity 106 (CAS 110464-72-7)
Recommended Standards
- Edaravone Impurity 26 (CAS 96-96-8)
- Lansoprazole Impurity 24 (CAS 168167-49-5)
- 4-Methanehydrazonoylbenzene-1,2,3-triol (CAS 1865681-56-6)
- Lansoprazole Impurity 34 (CAS 1357726-93-2)
- Riociguat Impurity 15 (CAS CATO-C4X-174915)
- Cefepime impurity 37 (CAS CATO-C4X-119337)
- Lomefloxacin Impurity 2 (CAS 99726-76-8)
- 4-fluoro-2-(1-methyl-1H-pyrazol-4-yl)aniline (CAS 1183800-47-6)
- 6-Chloro-8-methylquinoline-2-carbaldehyde (CAS 904886-39-1)
- (4-Bromophenyl)(4-methoxy-2-methylphenyl)methanol (CAS 1283139-21-8)
- N’-(pyridin-3-yl)benzenecarboximidamide (CAS 19673-11-1)
- 4-Chloro-2-(3-fluoropyridin-2-yl)-5-isopropylpyrimidine (CAS 2119574-84-2)
- N-Cbz-4-Piperidinecarboxylic acid (CAS 10314-98-4)
- D-Val23-Tirzepatide (CAS CATO-CPTD788911)
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