Esomeprazole Impurity 66 CAS 14248-66-9
| CAS No. | 14248-66-9 |
| Molecular Formula | C7H8N2O3 |
| Molecular Weight | 168.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 168.15 g/mol gives Esomeprazole Impurity 66 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Esomeprazole Impurity 66 (CAS 14248-66-9) is a certified pharmaceutical impurity reference standard with the molecular formula C7H8N2O3 and a molecular weight of 168.15 g/mol.
Based on its molecular formula C7H8N2O3, Esomeprazole Impurity 66 contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 168.15 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H8N2O3 |
| Molecular Weight | 168.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Nitrogen Atoms | 2 |
Related Esomeprazole Standards
- Esomeprazole Impurity 28 (CAS 577-72-0)
- Esomeprazole Impurity 44 (CAS 16133-49-6)
- Esomeprazole Impurity 105 (CAS 86604-78-6)
- Esomeprazole Impurity 115 (CAS 1424857-83-9)
- Esomeprazole Impurity 40 (CAS 86604-80-0)
- Esomeprazole Impurity 39 (CAS 92806-98-9)
- Esomeprazole Impurity 97 (CAS 142885-88-9)
- Esomeprazole Impurity 106 (CAS 110464-72-7)
Recommended Standards
- Lansoprazole Impurity 24 (CAS 168167-49-5)
- Lansoprazole Impurity 34 (CAS 1357726-93-2)
- Edaravone Impurity 26 (CAS 96-96-8)
- Lansoprazole impurity 73 (CAS CATO-C4X-111373)
- Bisoprolol EP Impurity N Hemifumarate (CAS CATO-C4X-124738)
- Tigecycline Impurity 33 (CAS CATO-C4X-186033)
- Paricalcitol Impurity 26 (CAS CATO-C4X-138726)
- 6-Bromo-1H-indazol-7-ol (CAS 1638764-66-5)
- 3-Amino-1-[(1,1-Dimethylethoxy)Carbonyl]-3-Piperidineacetic Acid Methyl Ester (CAS 362706-09-0)
- Edaravone Impurity 27 (CAS 102-51-2)
- 4-(6-Chloropyrazin-2-yl)benzoic acid (CAS 1086379-53-4)
- N-(3-hydroxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide (CAS 412922-94-2)
- 4-tert-Butyl-3-nitroaniline (CAS 31951-12-9)
- Semaglutide impurity 260 (CAS CATO-C4X-2226260)
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