Sorafenib Impurity 41 CAS 1129683-83-5
| CAS No. | 1129683-83-5 |
| Molecular Formula | C14H10ClF3N2O2 |
| Molecular Weight | 330.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Sorafenib Impurity 41 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Sorafenib Impurity 41 (CAS 1129683-83-5), a pharmacopoeial impurity reference standard (molecular formula C14H10ClF3N2O2, MW 330.69 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Sorafenib Impurity 41 (C14H10ClF3N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 330.69 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C14H10ClF3N2O2 |
| Molecular Weight | 330.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Sorafenib Standards
- Sorafenib EP Impurity D (CAS 2206827-14-5)
- Sorafenib Impurity 13 (CAS CATO-C4X-112413)
- Sorafenib Impurity 4 (CAS 871555-75-8)
- Sorafenib Impurity 2(PAPE-ethyl carbamate) (CAS 2206827-12-3)
- Sorafenib impurity 64 (CAS CATO-C4X-112464)
- Sorafenib Impurity 29 (CAS CATO-C4X-112429)
- Sorafenib Impurity 35 (CAS CATO-C4X-112435)
- Sorafenib Impurity 11 (CAS 1129683-88-0)
Recommended Standards
- N-(4-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)acetamide (CAS 937604-89-2)
- 3-(3-Chloro-5-fluorophenyl)-1-(3-(trifluoromethyl)phenyl)propan-1-one (CAS 898751-00-3)
- Metaglidasen (CAS 23953-40-4)
- 3-(3-Chloro-5-fluorophenyl)-2-trifluoromethylpropiophenone (CAS 898750-97-5)
- Dapagliflozin Impurity 174 (CAS CATO-C4X-1138174)
- Chlorhexidine EP Impurity H (CAS CATO-C4X-225613)
- Labetalol Impurity 66 (CAS CATO-C4X-246666)
- 2-Ethoxyethyl carbonochloridate (CAS 628-64-8)
- 2-Bromo-N-(3-methoxypropyl)benzenesulfonamide (CAS 848906-56-9)
- N-(tert-Butyl)isoxazole-5-carboxamide (CAS 126243-10-5)
- 2-Methyl-N-(thiazol-5-ylmethyl)butan-2-amine (CAS 1341907-13-8)
- (S)-N-Ethyl-N-(pyrrolidin-2-ylmethyl)ethanamine (CAS 51207-65-9)
- 2-(Dodecylthio)-N-(4-fluorophenyl)acetamide (CAS 331461-56-4)
- Peptide 438 (CAS CATO-CPTD788438)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com