Sorafenib Impurity 2(PAPE-ethyl carbamate) CAS 2206827-12-3
| CAS No. | 2206827-12-3 |
| Molecular Formula | C16H17N3O4 |
| Molecular Weight | 315.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Sorafenib Impurity 2(PAPE-ethyl carbamate) (CAS 2206827-12-3, C16H17N3O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C16H17N3O4, Sorafenib Impurity 2(PAPE-ethyl carbamate) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 315.32 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H17N3O4 |
| Molecular Weight | 315.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 3 |
Related Sorafenib Standards
- Sorafenib Impurity 4 (CAS 871555-75-8)
- Sorafenib Impurity 13 (CAS CATO-C4X-112413)
- Sorafenib impurity 64 (CAS CATO-C4X-112464)
- Sorafenib EP Impurity D (CAS 2206827-14-5)
- Sorafenib Impurity 41 (CAS 1129683-83-5)
- Sorafenib Impurity 29 (CAS CATO-C4X-112429)
- Sorafenib Impurity 11 (CAS 1129683-88-0)
- Sorafenib Impurity 56 (CAS 864272-34-4)
Recommended Standards
- Mirabegron Impurity 91 (CAS 3032026-53-9)
- Levofloxacin Impurity 17 (CAS CATO-C4X-137117)
- Mirabegron Impurity 121 (CAS CATO-C4X-1032121)
- Levofloxacin impurity 66 (CAS CATO-C4X-137166)
- Olmesartan Impurity 36 (CAS 1092980-84-1)
- Cladribine Impurity 3 (CAS 77-73-6)
- Cefotaxime Impurity 65 (CAS CATO-C4X-120165)
- 1-(3,6-Dichloropyridazin-4-yl)-2,2,2-trifluoroethanone (CAS 1391766-42-9)
- 1-(2-Chloro-6,7-dimethoxyquinolin-3-yl)ethanone (CAS 94741-42-1)
- methyl 9-ethyl-1-(hydroxymethyl)pyrido[3,4-b]indole-3-carboxylate (CAS 2668259-67-2)
- N1,N1-Dihexadecyl-N4-(3-(triethoxysilyl)propyl)succinamide (CAS 244096-38-6)
- Nebivolol Impurity 101 (CAS CATO-C4X-1968101)
- 3-(2-Formylphenyl)benzo[d]isoxazole-6-carboxylic acid (CAS 1261604-08-3)
- Mast Cell Degranulating (MCD) Peptide HR-2 (CAS 80388-04-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com