Bortezomib Impurity 5 CAS 1132709-16-0
| CAS No. | 1132709-16-0 |
| Molecular Formula | C19H25BN4O4 |
| Molecular Weight | 384.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Bortezomib Impurity 5 (C19H25BN4O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Bortezomib Impurity 5 (CAS 1132709-16-0) is a certified pharmaceutical impurity reference standard with the molecular formula C19H25BN4O4 and a molecular weight of 384.24 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H25BN4O4 |
| Molecular Weight | 384.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 4 |
Related Bortezomib Standards
- Bortezomib (CAS 179324-69-7)
- Bortezomib Impurity 35 (CAS 1104011-35-9)
- Bortezomib Impurity 6 (CAS 1132709-14-8)
- Bortezomib Impurity 7 (CAS 1132709-15-9)
- Bortezomib Impurity 14 (CAS CATO-C4X-107214)
- Bortezomib Impurity 15 (CAS CATO-C4X-107215)
- Bortezomib Impurity 8 (CAS 886979-81-3)
- Bortezomib Impurity 9 (CAS 886979-78-8)
Recommended Standards
- N-(5-Iodopyridin-2-yl)-2-(p-tolylthio)acetamide (CAS 540760-23-4)
- 2-(5-Bromo-2-(tosylimino)pyridin-1(2H)-yl)acetamide (CAS 1005785-49-8)
- N-(4-bromophenyl)-N-tosylglycine (CAS 333453-95-5)
- S-(-)-Felodipine (CAS 105618-03-9)
- Erlotinib Impurity 108 (CAS 311-28-4)
- Clopidogrel Impurity 130 (CAS CATO-C4X-1029130)
- Linagliptin Impurity 26 (CAS CATO-C4X-110126)
- 2-Chloro-N,N-dipropylpyridin-4-amine (CAS 851886-35-6)
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- 67492-15-3 N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-pentadecanamide (CAS 67492-15-3)
- 7-bromo-5-fluoro-1,2,3,4-tetrahydroquinoline hydrochloride (CAS 1432681-93-0)
- 4-(2H-1,2,3-Triazol-2-yl)benzenemethanol (CAS 449211-78-3)
- Myelin Basic Protein (85-99) Peptide Antagonist (CAS 444305-16-2)
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