Clotrimazole EP Impurity B CAS 23593-71-7
| CAS No. | 23593-71-7 |
| Molecular Formula | C22H17ClN2 |
| Molecular Weight | 344.84 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 344.84 g/mol gives Clotrimazole EP Impurity B distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Clotrimazole EP Impurity B (CAS 23593-71-7, C22H17ClN2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Clotrimazole EP Impurity B (C22H17ClN2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 344.84 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H17ClN2 |
| Molecular Weight | 344.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Clotrimazole Standards
- Clotrimazole TRAM-34 Impurity (CAS 289905-88-0)
- Clotrimazole Impurity 19 (CAS 23593-76-2)
- Clotrimazole (CAS 23593-75-1)
- Clotrimazole-d5 (CAS 1185076-41-8)
- Clotrimazole Impurity 23 (CAS 289887-34-9)
- Clotrimazole Impurity 24 (CAS 98751-53-2)
- Clotrimazole Impurity 29 (CAS 103855-36-3)
- Clotrimazole Impurity 9 (CAS 23593-68-2)
Recommended Standards
- Bifonazole Impurity 22 (CAS CATO-C4X-156022)
- Cetirizine Impurity N19 (CAS 113740-61-7)
- Clozapine EP Impurity D (CAS 65514-71-8)
- N-Acetyl Metoclopramide-d3 (CAS 105314-01-0)
- Cilnidipine Impurity 6 (CAS 146845-34-3)
- Ulipristal Impurity 28 (CAS 42982-49-0)
- Pemetrexed Impurity 20 (CAS CATO-C4X-172620)
- Methyl 4-(2,4-difluorophenyl)-3-oxobutanoate (CAS 942475-04-9)
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- 4-(4-(Tert-butyl)benzoyl)phenyl acetate (CAS 890099-70-4)
- 6-Nitro-1,2,3,4-tetrahydroisoquinoline (CAS 186390-77-2)
- 5-Chloro-3-isopropyl-1-methyl-1H-pyrazole-4-sulfonyl chloride (CAS 145980-84-3)
- 3-Bromo Lidocaine (CAS 1044658-01-6)
- Tirzepatide Impurity 10 (CAS CATO-C4X-324010)
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