Neratinib Impurity 21 CAS 1144516-15-3
| CAS No. | 1144516-15-3 |
| Molecular Formula | C28H24ClN5O4 |
| Molecular Weight | 529.97 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Neratinib Impurity 21 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Neratinib Impurity 21 (CAS 1144516-15-3), a pharmacopoeial impurity reference standard (molecular formula C28H24ClN5O4, MW 529.97 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Neratinib Impurity 21 (C28H24ClN5O4) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 19.0, corresponding to approximately 19 ring(s) or double-bond equivalent(s). With a molecular weight of 529.97 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C28H24ClN5O4 |
| Molecular Weight | 529.97 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Neratinib Standards
- Neratinib Impurity 13 (CAS 1144516-21-1)
- Neratinib Impurity 5 (CAS CATO-C4X-11345)
- Neratinib Impurity 54 (CAS CATO-C4X-113454)
- Neratinib Impurity 10 (CAS 1144516-13-1)
- Neratinib Impurity 14 (CAS 1144516-14-2)
- Neratinib Impurity 7 (CAS 915788-27-1)
- Neratinib Impurity 62 (CAS CATO-C4X-113462)
- Neratinib Impurity 17 (CAS 1144516-19-7)
Recommended Standards
- 4-((3R,3'S,3a'S,6a'R)-3'-Benzyl-6-chloro-7-methyl-2,4',6'-trioxo-2',3',3a',4',6',6a'-hexahydro-5'H-spiro[indoline-3,1'-pyrrolo[3,4-c]pyrrol]-5'-yl)phenyl acetate (CAS 956249-37-9)
- Ethyl 6-amino-4-(4-chlorophenyl)-5-cyano-2-(((5-cyano-[2,4'-bipyridin]-6-yl)thio)methyl)-4H-pyran-3-carboxylate (CAS 352662-78-3)
- Lutetium(III) carbonate (CAS 5895-53-4)
- (S)-1-((S)-2-((R)-2-((S)-2-Amino-3-(4-hydroxyphenyl)propanamido)propanamido)-3-(4-chlorophenyl)propanoyl)pyrrolidine-2-carboxamide (CAS 102029-97-0)
- Acetylcysteine impurity 69 (CAS CATO-C4X-153269)
- Pimavanserin Impurity 38 (CAS CATO-C4X-193838)
- Cycloserine Dimer Impurity (Cycloserine Diketoperazine) (CAS 16337-02-3)
- rel-(2R,4S)-4-Phenylpyrrolidine-2-carboxylic acid (CAS 1217806-82-0)
- 1-Benzyl-4-(4-methoxyphenyl)piperidine-4-carbonitrilehydrochloride (CAS 1189656-91-4)
- 2-(4-Chlorophenyl)-4-methylthiazole-5-carbohydrazide (CAS 685541-32-6)
- 4-{[3-(Trifluoromethyl)phenyl]methyl}oxane-4-carboxylic acid (CAS 1385696-63-8)
- 4-(4-amino-2,6-dimethylphenyl)morpholin-3-one (CAS 482308-12-3)
- 7-Bromo-4-chloroquinoline-3-carboxamide (CAS 1374867-81-8)
- Semaglutide impurity 276 (CAS CATO-C4X-2226276)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com