Neratinib Impurity 17 CAS 1144516-19-7
| CAS No. | 1144516-19-7 |
| Molecular Formula | C28H25ClN6O4 |
| Molecular Weight | 544.99 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Neratinib Impurity 17 (CAS 1144516-19-7), a pharmacopoeial impurity reference standard (molecular formula C28H25ClN6O4, MW 544.99 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C28H25ClN6O4, Neratinib Impurity 17 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 544.99 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Neratinib Impurity 17 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C28H25ClN6O4 |
| Molecular Weight | 544.99 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Neratinib Standards
- Neratinib Impurity 7 (CAS 915788-27-1)
- Neratinib Impurity 5 (CAS CATO-C4X-11345)
- Neratinib Impurity 2 (CAS 876310-02-0)
- Neratinib (CAS 698387-09-6)
- Neratinib Impurity 37 (CAS CATO-C4X-113437)
- Neratinib Impurity 30 (CAS CATO-C4X-113430)
- Neratinib Impurity 21 (CAS 1144516-15-3)
- Neratinib Impurity 13 (CAS 1144516-21-1)
Recommended Standards
- Tetraoctyl silicate (CAS 78-14-8)
- 3-Amino-N-(4-chloro-3-nitrophenyl)-4-(4-methoxyphenyl)-6-(p-tolyl)thieno[2,3-b]pyridine-2-carboxamide (CAS 337498-22-3)
- Tetrakis(2-ethylhexyl) Orthosilicate (CAS 115-82-2)
- Mometasone Furoate Impurity 23 (CAS 83897-05-6)
- Atomoxetine impurity 41 (CAS 1010818-92-4（free base）)
- Alectinib impurity 19 (CAS 1578259-67-2)
- Edoxaban Impurity 66 (CAS 1445-73-4)
- N-(3-Chlorophenyl)hydrazinecarboxamide (CAS 51707-42-7)
- Dihydroquinine hydrobromide (CAS 85153-19-1)
- 3-Bromo-4-(trifluoromethyl)benzaldehyde (CAS 372120-55-3)
- 4-Cyano-4-(dodecylsulfanylthiocarbonyl)sulfanylpentanoic acid 870196-80-8 4-Cyano-4-(((dodecylthio)carbonothioyl)thio)pentanoic acid (CAS 870196-80-8)
- N-cyclobutyl-3-(piperidin-2-yl)pyridin-2-amine (CAS 1352507-86-8)
- Cefpirome Impurity 28 (CAS CATO-C4X-120728)
- Semaglutide Impurity 161 (x TFA Salt) (CAS CATO-C4X-2226161)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com