Baricitinib Impurity 42 CAS 1146629-77-7
| CAS No. | 1146629-77-7 |
| Molecular Formula | C15H17N5O2 |
| Molecular Weight | 299.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Baricitinib Impurity 42 (CAS 1146629-77-7, C15H17N5O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C15H17N5O2, Baricitinib Impurity 42 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 299.33 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H17N5O2 |
| Molecular Weight | 299.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 5 |
Related Baricitinib Standards
- Baricitinib Impurity 41 (CAS CATO-C4X-226041)
- Baricitinib Impurity 110 (CAS CATO-C4X-2260110)
- Baricitinib Impurity 48 (CAS CATO-C4X-226048)
- Baricitinib Impurity 129 (CAS 3043892-25-4)
- Baricitinib Impurity 109 (CAS CATO-C4X-2260109)
- Baricitinib Impurity 93 (CAS CATO-C4X-226093)
- Baricitinib Impurity 122 (CAS CATO-C4X-2260122)
- Baricitinib Impurity 124 (CAS CATO-C4X-2260124)
Recommended Standards
- Upadacitinib Impurity 208 (CAS CATO-C4X-2405208)
- N-Phenylphenazine-1-carboxamide (CAS 3265-10-9)
- Upadacitinib Impurity 27 (CAS CATO-C4X-240527)
- N-(5-(((5-hydroxy-4-oxo-4H-pyran-2-yl)methyl)thio)-1,3,4-thiadiazol-2-yl)acetamide (CAS 2034154-82-8)
- N-Nitroso Cloxacillin Impurity 34 (CAS CATO-C4X-159734)
- Cladribine EP Impurity B (CAS 24757-70-8)
- Bisphenol A Impurity 3 (CAS 2300-15-4)
- N-(4-butylphenyl)-2-((4-chlorophenyl)thio)acetamide (CAS 195512-01-7)
- N-(1,3-Dioxoisoindolin-5-yl)furan-2-carboxamide (CAS 384804-34-6)
- 1-(3-Fluoro-5-(trifluoromethyl)phenyl)cyclopropanecarboxylic acid (CAS 1260780-99-1)
- 2-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridin-3-yl)acetic acid (CAS 1806530-96-0)
- 4-(Trifluoromethyl)-3-pyridinemethanol (CAS 198401-76-2)
- (4-Methoxy-3-(trifluoromethoxy)phenyl)methanamine (CAS 1261865-55-7)
- Liraglutide-d8 Tritrifluoroacetate (CAS CATO-C4X-199223)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com