Ruxolitinib Impurity 61 CAS 1146629-80-2
| CAS No. | 1146629-80-2 |
| Molecular Formula | C23H28N6O2 |
| Molecular Weight | 420.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ruxolitinib Impurity 61 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Ruxolitinib Impurity 61 (CAS 1146629-80-2, C23H28N6O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Ruxolitinib Impurity 61 (C23H28N6O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 420.51 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Ruxolitinib Impurity 61 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C23H28N6O2 |
| Molecular Weight | 420.51 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 6 |
Related Ruxolitinib Standards
- Ruxolitinib Impurity 20 (CAS CATO-C4X-205820)
- Ruxolitinib Impurity 34 (CAS 1236033-23-0)
- Ruxolitinib Impurity 69 (CAS 1236033-05-8)
- Ruxolitinib Impurity 67 (CAS CATO-C4X-205867)
- Ruxolitinib Impurity N2 (CAS 191605-10-4)
- Ruxolitinib Impurity 112 (CAS CATO-C4X-2058112)
- Ruxolitinib Impurity 89 (CAS CATO-C4X-205889)
- Ruxolitinib Impurity 42 (CAS CATO-C4X-205842)
Recommended Standards
- Fluocinolone Acetonide EP Impurity F (CAS 1526-01-8)
- 5,5'-(octane-1,1-diyl)bis(6-amino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione) (CAS 253195-26-5)
- Halcinonide Impurity N1 (CAS 3093-36-5)
- Methyl 7-((1R,2R,3R,5S)-2-(5-(2-fluorophenyl)-3-hydroxypent-4-yn-1-yl)-3,5-dihydroxycyclopentyl)heptanoate (CAS 291303-34-9)
- Cyproheptadine impurity 14 (CAS 34663-46-2)
- (7S)-Sitafloxacin Impurity N11 (CAS 127199-45-5)
- Esomeprazole EP Impurity D (CAS 88546-55-8)
- 2-(4-Ethylpiperazin-1-yl)isonicotinimidamide (CAS 1017026-82-2)
- 1,4-Dioxa-8-aza-spiro[4.5]decan-7-one (CAS 6813-54-3)
- 3-(3,4-Difluorophenyl)-4,4,4-trifluorobutanoic acid (CAS 1508417-38-6)
- 2-Chloro-1H-imidazo[4,5-c]pyridin-4-amine (CAS 668268-64-2)
- tert-Butyl 4-(isoquinolin-3-yl)piperazine-1-carboxylate (CAS 1042986-15-1)
- 3-[(4-Bromophenyl)sulfanyl]-2-(2,4-dichlorophenyl)quinoline-4-carboxylic acid (CAS 477886-47-8)
- a2,3-Sialylglycopeptide (CAS 189035-43-6)
Why CATO?
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