Tofacitinib Impurity 183 CAS 115093-90-8
| CAS No. | 115093-90-8 |
| Molecular Formula | C6H3Cl2N3 |
| Molecular Weight | 188.01 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 188.01 g/mol gives Tofacitinib Impurity 183 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Tofacitinib Impurity 183 (CAS 115093-90-8) is a certified pharmaceutical impurity reference standard with the molecular formula C6H3Cl2N3 and a molecular weight of 188.01 g/mol.
The molecular framework of Tofacitinib Impurity 183 (C6H3Cl2N3) is characterized by a nitrile group, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H3Cl2N3 |
| Molecular Weight | 188.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Tofacitinib Standards
- Tofacitinib Impurity 60 (CAS 90213-66-4)
- Tofacitinib Impurity 124 (CAS 14446-71-0)
- Tofacitinib Impurity 193 (CAS CATO-C4X-1079193)
- Tofacitinib Impurity 197 (CAS CATO-C4X-1079197)
- Tofacitinib impurity 195 (CAS CATO-C4X-1079195)
- Tofacitinib Impurity 149 (CAS 861612-04-6)
- Tofacitinib Impurity 221 (CAS CATO-C4X-1079221)
- Tofacitinib Impurity 155 (CAS 2032-35-1)
Recommended Standards
- 2,6-Dichlorobenzoxazole (CAS 3621-82-7)
- Ethene-1,1-diylbis(phosphonic acid) (CAS 34162-79-3)
- Chloroxynil (CAS 1891-95-8)
- 5,7-Dichloropyrazolo[1,5-a]pyrimidine (CAS 57489-77-7)
- LCZ-696 Impurity 31 (CAS CATO-C4X-169631)
- Chloropyramine Impurity 7 HCl (CAS 1135085-85-6)
- Gonadorelin EP Impurity E X TFA Salt (CAS CATO-C4X-23548)
- (E)-nona-2,8-dien-1-ol (CAS 100606-74-4)
- Ciclosporin Impurity 19 (CAS CATO-C4X-199819)
- 2-Amino-1-(3-((benzyl(isopropyl)amino)methyl)pyrrolidin-1-yl)ethanone (CAS 1353972-97-0)
- 7-Chloro-N-(pyridin-3-yl)thiazolo[5,4-d]pyrimidin-2-amine (CAS 871266-84-1)
- 3-Hydrazineyl-5-methylisoxazole (CAS 299170-19-7)
- N-(3-Bromo-4-methylphenyl)-1,3-propanesultam (CAS 1226343-78-7)
- Semaglutide (CAS CATO-C4X-2226105)
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