Tofacitinib Impurity 124 CAS 14446-71-0
| CAS No. | 14446-71-0 |
| Molecular Formula | C13H19N |
| Molecular Weight | 189.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Tofacitinib Impurity 124 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Tofacitinib Impurity 124 (CAS 14446-71-0, C13H19N) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C13H19N, Tofacitinib Impurity 124 contains a nitrogen-containing heterocyclic scaffold, a nitrile group; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 189.30 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tofacitinib Impurity 124 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H19N |
| Molecular Weight | 189.30 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Nitrogen Atoms | 1 |
Related Tofacitinib Standards
- Tofacitinib Impurity 183 (CAS 115093-90-8)
- Tofacitinib Impurity 60 (CAS 90213-66-4)
- Tofacitinib Impurity 193 (CAS CATO-C4X-1079193)
- Tofacitinib Impurity 197 (CAS CATO-C4X-1079197)
- Tofacitinib impurity 195 (CAS CATO-C4X-1079195)
- Tofacitinib Impurity 221 (CAS CATO-C4X-1079221)
- Tofacitinib Impurity 155 (CAS 2032-35-1)
- Tofacitinib Impurity 130 (CAS 2564-07-0)
Recommended Standards
- 3-[(4-Isopropylphenyl)methyl]azetidine 3-[[(4-(1-methylethyl)phenyl]methyl]azetidine 937622-20-3 (CAS 937622-20-3)
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- 1-Benzyl-2-methylpiperidine 777-38-8 (CAS 777-38-8)
- Indacaterol impurity 76 (CAS CATO-C4X-150076)
- Abemaciclib Impurity 137 (CAS CATO-C4X-2937137)
- Testosterone Impurity 41 (CAS CATO-C4X-243241)
- Ozagrel Impurity N2 (CAS 20754-20-5)
- 3-Chloro-N-((tetrahydro-2H-pyran-4-yl)methyl)aniline (CAS 1250728-27-8)
- 3-[(3-Methoxyphenyl)methyl]-3,4-dihydro-2H-1,3-benzothiazine-2,4-dione (CAS 338415-45-5)
- N-Butyl-N-(4-methylbenzyl)pyrrolidin-3-amine (CAS 820984-55-2)
- 2-(4-Methoxyphenyl)-4-oxo-4H-chromen-3-yl decanoate (CAS 306732-02-5)
- 2-((2,2-Difluorocyclopropyl)methoxy)benzaldehyde (CAS 1708401-82-4)
- 3,3-Bis(fluoromethyl)oxetane (CAS 338-61-4)
- Semaglutide impurity 86 (CAS CATO-C4X-222686)
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