Tofacitinib Impurity 60 CAS 90213-66-4
| CAS No. | 90213-66-4 |
| Molecular Formula | C6H3Cl2N3 |
| Molecular Weight | 188.01 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tofacitinib Impurity 60.
As a process- or degradation-related impurity, Tofacitinib Impurity 60 (CAS 90213-66-4, C6H3Cl2N3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Tofacitinib Impurity 60 (C6H3Cl2N3) contains a nitrile group, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 188.01 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Tofacitinib Impurity 60 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H3Cl2N3 |
| Molecular Weight | 188.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Tofacitinib Standards
- Tofacitinib Impurity 183 (CAS 115093-90-8)
- Tofacitinib Impurity 124 (CAS 14446-71-0)
- Tofacitinib Impurity 193 (CAS CATO-C4X-1079193)
- Tofacitinib Impurity 197 (CAS CATO-C4X-1079197)
- Tofacitinib impurity 195 (CAS CATO-C4X-1079195)
- Tofacitinib Impurity 149 (CAS 861612-04-6)
- Tofacitinib Impurity 221 (CAS CATO-C4X-1079221)
- Tofacitinib Impurity 155 (CAS 2032-35-1)
Recommended Standards
- Chloroxynil (CAS 1891-95-8)
- 2,6-Dichlorobenzoxazole (CAS 3621-82-7)
- 3-Amino-2-bromophenol (CAS 100367-36-0)
- Ethene-1,1-diylbis(phosphonic acid) (CAS 34162-79-3)
- Peficitinib Impurity 21 (CAS CATO-C4X-280721)
- Vitamin K1 Impurity 44 (CAS 873964-73-9)
- Amlodipine Besylate EP Impurity B (CAS 721958-72-1)
- Zuclopenthixol Succinate Salt - API Standards (CAS 1246833-58-8)
- 2-Amino-5-(4-fluorophenyl)isonicotinic acid (CAS 1214370-50-9)
- 2,6-diethylbenzoic acid (CAS 78114-07-5)
- 4-Aminobenzene-1-carbonimidoyl chloride hydrochloride (CAS 1378857-83-0)
- 4-Bromo-5-(cyclopropylamino)-2-(3,3-dimethyl-2-oxobutyl)-2,3-dihydropyridazin-3-one (CAS 320423-92-5)
- 6-Amino-1,3-dimethyl-3,4-dihydro-1H-quinolin-2-one (CAS 1267973-48-7)
- D-[Ser]8-Liraglutide (CAS CATO-C4X-199238)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com