Metoprolol Impurity 18 CAS 56718-70-8
| CAS No. | 56718-70-8 |
| Molecular Formula | C12H16O3 |
| Molecular Weight | 208.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Metoprolol Impurity 18 (CAS 56718-70-8) is a certified pharmaceutical impurity reference standard with the molecular formula C12H16O3 and a molecular weight of 208.25 g/mol.
Metoprolol Impurity 18 (C12H16O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Metoprolol Impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H16O3 |
| Molecular Weight | 208.25 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
Related Metoprolol Standards
- Metoprolol Impurity 9 (CAS 1155083-53-6)
- Metoprolol Impurity 29 (CAS 89507-60-8)
- Metoprolol Impurity 21 (CAS 84697-14-3)
- Metoprolol EP Impurity F (CAS 7695-63-8)
- Metoprolol Impurity 22 (CAS 123195-72-2)
- Metoprolol Impurity 17 (CAS 158553-31-2)
- Metoprolol Impurity 27 (CAS 40167-10-0)
- Metoprolol EP Impurity D (CAS 62572-90-1)
Recommended Standards
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- Bosutinib Impurity N3 (CAS 17722-32-6)
- Budesonide Impurity 39 (CAS 1436872-65-9)
- (S)-1-(4-Methyl-2'-(trifluoromethyl)-[3,4'-bipyridin]-6-yl)ethan-1-amine (CAS 1628106-86-4)
- 1,3-Bibromo-2-isopropoxy-5-isopropylbenzene (CAS 2379322-43-5)
- 2-[(Butylamino)methyl]-6-ethoxyphenol (CAS 1019490-15-3)
- Methyl 3-hydroxy-4-(hydroxymethyl)benzoate (CAS 71780-40-0)
- 2-Chloro-N-(2,3-dichlorobenzyl)-N-methylacetamide (CAS 1183592-43-9)
- 2-Isopropyl-4-phenyloxazol-5(2H)-one (CAS 60050-58-0)
- Tirzepatide Impurity 48 (CAS CATO-C4X-324048)
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