Metoprolol EP Impurity D CAS 62572-90-1
| CAS No. | 62572-90-1 |
| Molecular Formula | C12H18O4 |
| Molecular Weight | 226.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Metoprolol EP Impurity D is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Metoprolol EP Impurity D (CAS 62572-90-1, C12H18O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Metoprolol EP Impurity D (C12H18O4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 226.27 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Metoprolol EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H18O4 |
| Molecular Weight | 226.27 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
Related Metoprolol Standards
- Metoprolol Impurity 27 (CAS 40167-10-0)
- Metoprolol EP Impurity F (CAS 7695-63-8)
- Metoprolol Impurity 21 (CAS 84697-14-3)
- Metoprolol Impurity 9 (CAS 1155083-53-6)
- Metoprolol Impurity 18 (CAS 56718-70-8)
- Metoprolol Impurity 29 (CAS 89507-60-8)
- Metoprolol USP Related Compound B (CAS 56718-76-4)
- Metoprolol Impurity 51 (CAS 2517349-25-4)
Recommended Standards
- Flurbiprofen EP Impurity A(Flurbiprofen Related Compound A) (CAS 6341-72-6)
- Telmisartan Impurity 33 (CAS 114772-34-8)
- Ketoprofen impurity 75 (CAS 319482-67-2)
- Temozolomide Impurity 26 (CAS 13114-72-2)
- Loxoprofen Impurity 79 (CAS CATO-C4X-148879)
- Bumetanide Impurity 67 (CAS CATO-C4X-198667)
- Papaverine Impurity 15 (CAS 57170-09-9)
- (Z)-6,7-dihydroxyligustilide (CAS 106533-39-5)
- 4-Methyl-7-(((2R,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-one (CAS 1643953-00-7)
- ((3-Benzamidophenyl)azanediyl)bis(ethane-2,1-diyl) diacetate (CAS 43051-43-0)
- 2-(4-Ethyl-5-((naphthalen-1-ylmethyl)thio)-4H-1,2,4-triazol-3-yl)pyridine (CAS 578719-50-3)
- (2S,3R)-2-Amino-3-hydroxy-2-methylbutanoic acid (CAS 127126-06-1)
- Chlorphenamine Impurity 73 (CAS CATO-C4X-118873)
- D-Asp15-Tirzepatide (CAS CATO-CPTD788919)
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