Lesinurad Impurity 8 CAS 1158970-49-0
| CAS No. | 1158970-49-0 |
| Molecular Formula | C15H12BrN3O2S |
| Molecular Weight | 378.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Lesinurad Impurity 8 (CAS 1158970-49-0) is a certified pharmaceutical impurity reference standard with the molecular formula C15H12BrN3O2S and a molecular weight of 378.24 g/mol.
Structurally, Lesinurad Impurity 8 (C15H12BrN3O2S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 378.24 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H12BrN3O2S |
| Molecular Weight | 378.24 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Lesinurad Standards
- Lesinurad Impurity 11 (CAS CATO-C4X-147811)
- Lesinurad Impurity E (CAS 1210330-64-5)
- Lesinurad Impurity 17 (CAS CATO-C4X-147817)
- Lesinurad Impurity 1 (CAS 1533519-98-0)
- Lesinurad Impurity 6 (CAS CATO-C4X-14786)
- Lesinurad Impurity 33 (CAS 1533519-94-6)
- Lesinurad Impurity 4 (CAS 1533519-97-9)
- Lesinurad Impurity 13 (CAS CATO-C4X-147813)
Recommended Standards
- tert-Butyl (4-nitro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)carbamate (CAS 2377609-03-3)
- Tert-butyl (S)-4-(4-bromophenyl)-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide (CAS 1379546-69-6)
- Methyl 3-((tert-butoxycarbonyl)amino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate (CAS 2377606-60-3)
- Tert-butyl (S)-4-(3-bromophenyl)-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide (CAS 1379546-88-9)
- Mirabegron Impurity 51 (CAS 2092623-72-6)
- N-Nitroso Minocycline impurity 80 (CAS CATO-C4X-169980)
- Halobetasol Impurity 5 (CAS 79861-38-4)
- 1-(4-chlorophenyl)butan-2-one (CAS 83598-07-6)
- Methyl 5-chloro-6-cyanonicotinate (CAS 398457-04-0)
- Lythgoe Diol Monotosylate (CAS 66774-80-9)
- 2-Iodo-4,6-dimethoxybenzaldehyde (CAS 16147-09-4)
- Sodium 7-ethoxynaphthalene-2-sulfonate (CAS 1624260-51-0)
- 6-Amino-1-isobutyl-3-methyl-5-nitroso-2,4-pyrimidinedione (CAS 54052-67-4)
- Semaglutide impurity 255 (CAS CATO-C4X-2226255)
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