Dasatinib Impurity 5 CAS 1159977-13-5
| CAS No. | 1159977-13-5 |
| Molecular Formula | C25H30ClN7O3S |
| Molecular Weight | 544.07 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Dasatinib Impurity 5 (CAS 1159977-13-5) is a certified pharmaceutical impurity reference standard with the molecular formula C25H30ClN7O3S and a molecular weight of 544.07 g/mol.
Structurally, Dasatinib Impurity 5 (C25H30ClN7O3S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 544.07 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Dasatinib Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H30ClN7O3S |
| Molecular Weight | 544.07 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 7 |
| Sulfur Atoms | 1 |
Related Dasatinib Standards
- Dasatinib Carboxylic Acid Ethyl Ester (CAS 910297-62-0)
- Dasatinib Impurity 6 (CAS CATO-C4X-16076)
- Dasatinib Impurity 64 (CAS 2468737-75-7)
- Dasatinib Impurity 65 (CAS 2468737-76-8)
- Dasatinib Impurity 66 (CAS 2468737-89-3)
- Dasatinib Impurity 7 (CAS CATO-C4X-16077)
- Dasatinib Impurity 8 (CAS CATO-C4X-16078)
- Dasatinib Impurity 30 (CAS 1417651-54-7)
Recommended Standards
- Chloro{(1S,2S)-1,2-diphenyl-1-[(3-(η6-phenyl)propyl)amino]-2-(methylsulfonylamido)}ruthenium(II) (CAS 1437326-26-5)
- 2,4,6-Tris(3-bromophenyl)pyridine (CAS 1360743-16-3)
- Chloro{(1R,2R)-1,2-diphenyl-1-[(3-(η6-phenyl)propyl)amino]-2-(methylsulfonylamido)}ruthenium(II) (CAS 1361415-88-4)
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- 2-(4-Bromophenyl)tetrahydrofuran (CAS 194725-15-0)
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- 2-Oxo-3-phenylbutanoic acid (CAS 4658-69-9)
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