3,4-Difluoro-5-ethoxyphenylboronic acid CAS 1162261-96-2
| CAS No. | 1162261-96-2 |
| Molecular Formula | C8H9BF2O3 |
| Molecular Weight | 201.96 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 3,4-Difluoro-5-ethoxyphenylboronic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
3,4-Difluoro-5-ethoxyphenylboronic acid (CAS 1162261-96-2) is a high-purity analytical reference standard with the molecular formula C8H9BF2O3 and a molecular weight of 201.96 g/mol.
The molecular framework of 3,4-Difluoro-5-ethoxyphenylboronic acid (C8H9BF2O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H9BF2O3 |
| Molecular Weight | 201.96 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
Related Difluoro Standards
- 3,4-Difluoro-2-ethoxyphenylboronic acid (CAS 1451391-69-7)
- 2,4-Difluoro-3-methoxy-5-methylphenylboronic acid (CAS 2096331-81-4)
- 2,6-Difluoro-3-ethoxyphenylboronic acid (CAS 849062-00-6)
- 3,5-Difluoro-4-methoxy-2-methylphenylboronic acid (CAS 2096338-65-5)
- 2,2-Difluoro-1,3-benzodioxole-5-boronic Acid (CAS 190903-71-0)
- 2,2-Difluoro-1,3-benzodioxole-5-carboxylic Acid (CAS 656-46-2)
- 2,4-Difluoro-5-nitrobenzamide (CAS 1097799-57-9)
- 2,6-Difluoro-3-nitrobenzamide (CAS 124169-54-6)
Recommended Standards
- Ferrous Bisglycinate (CAS 20150-34-9)
- (6-Ethoxy-2,3-difluorophenyl)boronic acid (CAS 1309980-95-7)
- 5-(Trifluoromethyl)benzo[c][1,2]oxaborol-1(3H)-ol (CAS 174671-50-2)
- (4-Ethoxy-2,6-difluorophenyl)boronic acid (CAS 1310403-94-1)
- 5-Fluoro-2-methoxybenzyl Alcohol (CAS 426831-32-5)
- TAK 715 (CAS 303162-79-0)
- 4,7,8-Trimethyl-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one (CAS 65847-12-3)
- (2e)-3-[5-(2-fluorophenyl)thiophen-2-yl]prop-2-enoic acid (CAS 949977-46-2)
- tert-Butyl 1-bromo-2-oxo-6,9,12,15,18,21-hexaoxa-3-azatetracosan-24-oate (CAS 1609108-70-4)
- Dapsone-d8(major) (CAS 557794-38-4)
- 1-(Hydroxymethyl)-3,4,4-trimethyl-1H-pyrazol-5(4H)-one (CAS 51355-45-4)
- Gefitinib Impurity 86 (CAS CATO-C4X-111786)
- N-phenylpiperazine-1-carboxamide hydrochloride (CAS 474711-91-6)
- Acetyl Hexapeptide-39 (CAS 1382088-38-1)
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