Lansoprazole Impurity 50 CAS 116418-99-6
| CAS No. | 116418-99-6 |
| Molecular Formula | C7H7ClN2O2 |
| Molecular Weight | 186.60 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Lansoprazole Impurity 50 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Lansoprazole Impurity 50 (CAS 116418-99-6, C7H7ClN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Lansoprazole Impurity 50 (C7H7ClN2O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C7H7ClN2O2 |
| Molecular Weight | 186.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Lansoprazole Standards
- Lansoprazole Impurity 61 (CAS 2288740-69-0)
- Lansoprazole Impurity 36 (CAS 58536-71-3)
- Lansoprazole Impurity 68 (CAS 168167-48-4)
- Lansoprazole Impurity 4 (CAS 59886-84-9)
- Lansoprazole Impurity 24 (CAS 168167-49-5)
- Lansoprazole Impurity 34 (CAS 1357726-93-2)
- Lansoprazole impurity 73 (CAS CATO-C4X-111373)
- Lansoprazole Impurity 9 (CAS 37699-43-7)
Recommended Standards
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- Metoclopramide Impurity 14 (CAS CATO-C4X-141514)
- Phoxim Impurity 6 (CAS 14816-16-1)
- Diazepam Impurity 10 (CAS CATO-C4X-146510)
- Glumetinib Impurity 12 (CAS CATO-C4X-325912)
- 2-((4-(1-Methyl-1h-pyrazol-4-yl)-6-(trifluoromethyl)pyrimidin-2-yl)thio)acetic acid (CAS 1006440-64-7)
- 2-(2-(Difluoromethoxy)-4-hydroxybenzoyl)pyridine (CAS 1261728-86-2)
- 4-Fluoro-2-methoxy-N-methylaniline (CAS 941294-13-9)
- 2-((2,5-Difluorophenyl)thio)acetaldehyde (CAS 1249409-65-1)
- Fovinaciclib Impurity 5 (CAS CATO-C4X-33865)
- 3-Hydroxy-2,3-dimethylbutan-2-yl hydrogen (2-amino-4-ethylpyrimidin-5-yl)boronate (CAS 2223042-99-5)
- Tirzepatide Impurity 33 (CAS CATO-C4X-324033)
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