Lenvatinib Impurity 142 CAS 1069122-99-1
| CAS No. | 1069122-99-1 |
| Molecular Formula | C7H7ClN2O2 |
| Molecular Weight | 186.60 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Lenvatinib Impurity 142 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Lenvatinib Impurity 142 (CAS 1069122-99-1, C7H7ClN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Lenvatinib Impurity 142 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 186.60 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C7H7ClN2O2 |
| Molecular Weight | 186.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Lenvatinib Standards
- Lenvatinib Impurity 102 (CAS 15568-85-1)
- Lenvatinib Impurity 99 (CAS 756488-67-2)
- Lenvatinib Impurity 175 (CAS CATO-C4X-1140175)
- Lenvatinib Impurity 70 (CAS 56962-03-9)
- Lenvatinib Impurity N1 (CAS 28443-57-4)
- Lenvatinib Impurity 129 (CAS 26271-75-0)
- Lenvatinib Impurity 115 (CAS 106868-33-1)
- Lenvatinib Impurity 10 (CAS 97480-55-2)
Recommended Standards
- Lansoprazole Impurity 50 (CAS 116418-99-6)
- Metoclopramide Impurity 14 (CAS CATO-C4X-141514)
- N'-(2-Chloropyrimidin-4-yl)acetohydrazide (CAS 917757-34-7)
- Minoxidil Impurity 24 (CAS CATO-C4X-170024)
- Lafutidine impurity 22 (CAS CATO-C4X-147622)
- Gabapentin EP Impurity G (CAS 1500558-49-5)
- Ketorolac Impurity 55 (CAS CATO-C4X-166955)
- 3-(3,4-Dihydro-1H-carbazol-9(2H)-yl)-N'-(furan-2-ylmethylene)propanehydrazide (CAS 612047-90-2)
- Neostigmine Impurity 11 (CAS 39218-17-2)
- N-(2-(3-(Furan-2-yl)-6-oxopyridazin-1(6H)-yl)ethyl)-2-(trifluoromethyl)benzamide (CAS 946365-36-2)
- Methyl 2-(3,5-dimethyl-1H-pyrazol-1-yl)acetate (CAS 79559-08-3)
- {2-oxabicyclo[2.2.2]octan-4-yl}methanol (CAS 2168235-11-6)
- Methyl 7-(tert-butyl)-5-chloroimidazo[1,2-a]pyrimidine-2-carboxylate (CAS 1114822-96-6)
- Liraglutide Impurity 13 TFA Salt (CAS CATO-C4X-199213)
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