Nintedanib Impurity 14 CAS 1168150-46-6
| CAS No. | 1168150-46-6 |
| Molecular Formula | C18H15NO4 |
| Molecular Weight | 309.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 309.32 g/mol gives Nintedanib Impurity 14 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Nintedanib Impurity 14 (CAS 1168150-46-6, C18H15NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Nintedanib Impurity 14 (C18H15NO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 309.32 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H15NO4 |
| Molecular Weight | 309.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 1 |
Related Nintedanib Standards
- Nintedanib Impurity 120 (CAS CATO-C4X-1814120)
- Nintedanib Impurity 121 (CAS CATO-C4X-1814121)
- Nintedanib Impurity 53 (CAS 1160293-22-0)
- Nintedanib Impurity 55 (CAS 1438271-13-6)
- Nintedanib Impurity 36 (CAS 1160293-27-5)
- Nintedanib impurity 79 (CAS 2490403-92-2)
- Nintedanib Impurity 186 (CAS CATO-C4X-1814186)
- Nintedanib Impurity 122 (CAS CATO-C4X-1814122)
Recommended Standards
- Indobufen impurity 76 (CAS CATO-C4X-179276)
- Roxadustat Impurity 39 (CAS CATO-C4X-221339)
- Indobufen Impurity 71 (CAS CATO-C4X-179271)
- Roxadustat Impurity 73 (CAS CATO-C4X-221373)
- Rifabutin Impurity 14 (CAS CATO-C4X-251214)
- Resmetirom Impurity 44 (CAS CATO-C4X-291244)
- Carfilzomib Impurity 41 (CAS CATO-C4X-102241)
- Hydroxysafflor Yellow A (CAS 78281-02-4)
- (Tetrahydro-2h-pyran-4-yl)(m-tolyl)methanamine (CAS 1339685-19-6)
- 6λ⁶-thia-2-azaspiro[3.4]octane 6,6-dioxide;hydrochloride (CAS 2306261-59-4)
- Santicizer® 261 (CAS 68515-40-2)
- (1S,2S)-1-Hydroxy-1,2-dihydronaphthalen-2-yl benzoate (CAS 359820-45-4)
- P-styrenesulfonicacidpotassiumsalt (CAS 26638-29-9)
- D-Phe6-Tirzepatide (CAS CATO-CPTD788925)
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