Nintedanib Impurity 53 CAS 1160293-22-0
| CAS No. | 1160293-22-0 |
| Molecular Formula | C18H15NO4 |
| Molecular Weight | 309.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nintedanib Impurity 53.
CATO supplies Nintedanib Impurity 53 (CAS 1160293-22-0), a pharmacopoeial impurity reference standard (molecular formula C18H15NO4, MW 309.32 g/mol) used for the identification and quantification of trace impurities in APIs.
Nintedanib Impurity 53 (C18H15NO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nintedanib Impurity 53 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H15NO4 |
| Molecular Weight | 309.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 1 |
Related Nintedanib Standards
- Nintedanib Impurity 120 (CAS CATO-C4X-1814120)
- Nintedanib Impurity 121 (CAS CATO-C4X-1814121)
- Nintedanib Impurity 14 (CAS 1168150-46-6)
- Nintedanib Impurity 55 (CAS 1438271-13-6)
- Nintedanib Impurity 36 (CAS 1160293-27-5)
- Nintedanib impurity 79 (CAS 2490403-92-2)
- Nintedanib Impurity 186 (CAS CATO-C4X-1814186)
- Nintedanib Impurity 122 (CAS CATO-C4X-1814122)
Recommended Standards
- Roxadustat Impurity 39 (CAS CATO-C4X-221339)
- Roxadustat Impurity 73 (CAS CATO-C4X-221373)
- Indobufen impurity 76 (CAS CATO-C4X-179276)
- Mebendazole EP Impurity D (CAS 132119-11-0)
- Semaglutide Impurity 8 (CAS CATO-C4X-22268)
- Roxithromycin Impurity 19 (CAS 1460313-73-8)
- Palbociclib Impurity 138 (CAS CATO-C4X-1125138)
- N-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-2,2,2-trifluoro-N-methylacetohydrazide (CAS 1823183-98-7)
- 2-[(2,4-Dimethylphenyl)methyl]-4-(5-ethyl-1,2,4-oxadiazol-3-yl)-1H,2H,3H,5H,6H,7H,8H-pyrido[1,2-c]pyrimidine-1,3-dione (CAS 1775554-06-7)
- 2-Methyl-5,6,7,8-tetrahydroquinoline-4-carbaldehyde (CAS 1373757-77-7)
- 3-(((4-Chlorophenyl)sulfonyl)methyl)-N'-(1-(6-fluoropyridin-2-yl)piperidin-4-ylidene)-4-nitrobenzohydrazide (CAS 339016-42-1)
- 1-(Trimethylsilyl)-3,4-dichlorobenzene (CAS 149021-03-4)
- N-methyl-2-(thiophene-2-carbonyl)hydrazine-1-carbothioamide (CAS 116850-74-9)
- Peptide Impurity 64 (CAS CATO-CPTD788964)
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