Nintedanib Impurity 55 CAS 1438271-13-6
| CAS No. | 1438271-13-6 |
| Molecular Formula | C18H15NO4 |
| Molecular Weight | 309.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Nintedanib Impurity 55 (CAS 1438271-13-6), a pharmacopoeial impurity reference standard (molecular formula C18H15NO4, MW 309.32 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Nintedanib Impurity 55 (C18H15NO4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H15NO4 |
| Molecular Weight | 309.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 1 |
Related Nintedanib Standards
- Nintedanib Impurity 120 (CAS CATO-C4X-1814120)
- Nintedanib Impurity 121 (CAS CATO-C4X-1814121)
- Nintedanib Impurity 14 (CAS 1168150-46-6)
- Nintedanib Impurity 53 (CAS 1160293-22-0)
- Nintedanib Impurity 36 (CAS 1160293-27-5)
- Nintedanib impurity 79 (CAS 2490403-92-2)
- Nintedanib Impurity 186 (CAS CATO-C4X-1814186)
- Nintedanib Impurity 122 (CAS CATO-C4X-1814122)
Recommended Standards
- Roxadustat Impurity 39 (CAS CATO-C4X-221339)
- Roxadustat Impurity 73 (CAS CATO-C4X-221373)
- Mebendazole EP Impurity D (CAS 132119-11-0)
- Ozenoxacin Impurity 4 (CAS CATO-C4X-27964)
- Isoprenaline Impurity 26 (CAS CATO-C4X-277526)
- Pirfenidone EP Impurity A (CAS 1603-41-4)
- Eltrombopag Impurity 117 (CAS CATO-C4X-1198117)
- 3-Methyl-1-(2-methylfuran-3-carbonyl)pyrrolidine-3-carboxylic acid (CAS 1282674-65-0)
- 1-(6-Formylquinazolin-4-yl)ethyl piperidine-4-carboxylate (CAS 648449-20-1)
- (3AR,5R,6S,6aR)-5-Allyl-2,2-dimethyltetrahydrofuro-[2,3-d][1,3]dioxol-6-ol (CAS 546141-37-1)
- 2-(4-Bromo-2,6-difluorophenyl)-1,3-dioxolane (CAS 773087-43-7)
- Spiro[2.5]octan-6-amine hydrochloride (CAS 1256256-54-8)
- 2-Azetidinomethyl-4-bromo-2-fluorobenzophenone (CAS 898755-13-0)
- Neuropeptide Y (free acid) (human, rat) trifluoroacetate salt (CAS 99575-89-0)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com