Hydrocortisone EP Impurity J CAS 16463-74-4
| CAS No. | 16463-74-4 |
| Molecular Formula | C23H32O6 |
| Molecular Weight | 404.50 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Hydrocortisone EP Impurity J (C23H32O6) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Hydrocortisone EP Impurity J (CAS 16463-74-4) is a certified pharmaceutical impurity reference standard with the molecular formula C23H32O6 and a molecular weight of 404.50 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Hydrocortisone EP Impurity J meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H32O6 |
| Molecular Weight | 404.50 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
Related Hydrocortisone Standards
- Hydrocortisone Acetate EP Impurity F (CAS 1250-97-1)
- Hydrocortisone EP Impurity C (CAS 50-03-3)
- Hydrocortisone Impurity 30 (CAS CATO-C4X-140130)
- Hydrocortisone Impurity 51 (CAS CATO-C4X-140151)
- Hydrocortisone Impurity 69 (CAS 2905373-61-5)
- Hydrocortisone Impurity 36 (CAS 116846-74-3)
- Hydrocortisone 17-Propionate (CAS 65980-97-4)
- Hydrocortisone 21-Propionate (CAS 6677-98-1)
Recommended Standards
- Salbutamol Impurity 173 (CAS CATO-C4X-1176173)
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