Omarigliptin Impurity 3 CAS 951127-25-6
| CAS No. | 951127-25-6 |
| Molecular Formula | C16H19F2NO4 |
| Molecular Weight | 327.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Omarigliptin Impurity 3 (CAS 951127-25-6, C16H19F2NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Omarigliptin Impurity 3 (C16H19F2NO4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Omarigliptin Impurity 3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H19F2NO4 |
| Molecular Weight | 327.32 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Omarigliptin Standards
- Omarigliptin Impurity 4 (CAS 1456616-42-4)
- Omarigliptin Impurity 5 (CAS 1456616-44-6)
- Omarigliptin Impurity 6 (CAS 1456616-43-5)
- Omarigliptin Impurity 7 (CAS CATO-C4X-11477)
- Omarigliptin Impurity 8 (CAS CATO-C4X-11478)
- Omarigliptin Impurity 2 (CAS 1172623-99-2)
- Omarigliptin Impurity 16 (CAS 1819364-01-6)
- Omarigliptin Impurity 1 (CAS 1172623-98-1)
Recommended Standards
- 338409-45-3 5-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl cyclopropanecarboxylate KS-00001VFH (CAS 338409-45-3)
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- 3-Nitro-4-((1-phenyl-1H-tetrazol-5-yl)thio)benzaldehyde (CAS 461439-08-7)
- 3-(Trifluoromethyl)benzyl 2-(methylthio)nicotinate (CAS 485370-72-7)
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- Abemaciclib Impurity 138 (CAS CATO-C4X-2937138)
- Rivaroxaban Impurity 13 (CAS 721401-53-2)
- 4-Methyl-2,3-dihydrothieno[2,3-c]furan (CAS 100103-52-4)
- (1s)-2,2,2-Trifluoro-1-(3-fluoro-4-methoxyphenyl)ethan-1-amine hydrochloride (CAS 1807937-69-4)
- 2-Bromodibenzo[b,e][1,4]dioxine (CAS 105906-36-3)
- 6-Chloro-3-(methoxymethyl)[1,2,4]triazolo[4,3-b]pyridazine (CAS 1204296-35-4)
- 5-Chloro-1-(4-methylbenzyl)-6-oxo-1,6-dihydropyridine-3-carbaldehyde (CAS 1048913-54-7)
- Evocalcet impurity 60 (CAS 247034-96-4)
- 302798-54-5 (Leu31,Pro34)-Neuropeptide Y (13-36) (human, rat) MFCD00672463 (CAS 302798-54-5)
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