Levofloxacin Impurity 43 CAS 117620-84-5
| CAS No. | 117620-84-5 |
| Molecular Formula | C13H10FNO4 |
| Molecular Weight | 263.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Levofloxacin Impurity 43.
As a process- or degradation-related impurity, Levofloxacin Impurity 43 (CAS 117620-84-5, C13H10FNO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Levofloxacin Impurity 43 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 263.22 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H10FNO4 |
| Molecular Weight | 263.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Levofloxacin Standards
- Levofloxacin impurity 71 (CAS CATO-C4X-137171)
- Levofloxacin impurity 91 (CAS 151250-74-7)
- Levofloxacin Impurity 20 (CAS 2206360-62-3)
- Levofloxacin impurity 72 (CAS CATO-C4X-137172)
- Levofloxacin Impurity 101 (CAS 105804-40-8)
- Levofloxacin Impurity 102 (CAS 1260774-13-7)
- Levofloxacin EP Impurity F (CAS 100986-89-8)
- Levofloxacin Impurity 16 (CAS 82419-35-0)
Recommended Standards
- 1310AF 5-Ethyl-7-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid 876708-67-7 C10H12F3N3O2 (CAS 876708-67-7)
- N4-(3-fluorophenyl)-5-methylisoxazole-3,4-dicarboxamide (CAS 338792-90-8)
- Enrofloxacin Impurity 12 (CAS 130579-27-0)
- N1-(4-nitro-2-(trifluoromethyl)phenyl)propane-1,3-diamine (CAS 381241-12-9)
- Dalilesen Impurity 29 (CAS CATO-C4X-301029)
- Dotinurad Impurity 209 (CAS 935837-90-4)
- Evocalcet impurity 51 (CAS CATO-C4X-248551)
- 4-Bromo-1-(sec-butyl)-3-(methoxymethyl)-1H-pyrazole (CAS 1856031-25-8)
- Mefatinib Impurity 13 (CAS CATO-C4X-299213)
- (R)-4-(3-Bromophenyl)-3-((tert-butoxycarbonyl)amino)butanoic acid (CAS 1350734-63-2)
- 2-Iodo-6-methyl-4-nitroaniline (CAS 220144-91-2)
- Methyl 3-(2-(2-((4-fluorophenyl)amino)-2-oxoacetyl)-1H-pyrrol-1-yl)thiophene-2-carboxylate (CAS 477857-76-4)
- 2-((3-Chloro-4-fluorophenyl)amino)-N-(4-(piperidin-1-ylsulfonyl)phenyl)acetamide (CAS 853695-44-0)
- Tirzepatide Impurity 23 X TFA Salt (CAS CATO-C4X-324023)
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