Betamethasone Dipropionate EP Impurity G CAS 1186048-33-8
| CAS No. | 1186048-33-8 |
| Molecular Formula | C31H41FO8 |
| Molecular Weight | 560.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Betamethasone Dipropionate EP Impurity G (CAS 1186048-33-8, C31H41FO8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system, Betamethasone Dipropionate EP Impurity G is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 560.65 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C31H41FO8 |
| Molecular Weight | 560.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
Related Betamethasone Standards
- Betamethasone Valerate EP Impurity G (CAS CATO-C4X-143722)
- Betamethasone β-D-Glucuronide (CAS 744161-79-3)
- Betamethasone impurity 95 (CAS 1815577-58-2)
- Betamethasone Dipropionate impurity 02 (CAS 1186048-34-9)
- Betamethasone Dipropionate EP Impurity H (CAS 2575516-37-7)
- Betamethasone Impurity 110 (CAS CATO-C4X-1437110)
- Betamethasone Valerate EP Impurity D (CAS 3081732-65-9)
- Betamethasone impurity 58 (CAS CATO-C4X-143758)
Recommended Standards
- Suc-Phe-Gly-Leu-βNA (CAS 202000-07-5)
- 1-((2R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (CAS 125258-60-8)
- Entrectinib (CAS 1108743-60-7)
- DY 268 (CAS 1609564-75-1)
- Finerenone Impurity 206 (CAS CATO-C4X-2880206)
- Metformin Impurity 20 (CAS CATO-C4X-122020)
- Penehyclidine impurity 13 (CAS 4397-01-7)
- 1-Chloro-3-(3,3,3-trifluoropropyl)benzene (CAS 1099597-34-8)
- N-[2,4-Bis(morpholin-4-yl)phenyl]-2-phenyl-2H-1,2,3-triazole-4-carboxamide (CAS 872431-17-9)
- 2-(2,5-Dimethyl-1H-pyrrol-1-yl)-5-(pyrrolidin-2-yl)pyridine (CAS 1352522-37-2)
- 2-(chloromethyl)-5-(4-fluorophenyl)-1,3-oxazole (CAS 64640-14-8)
- 2-Fluoro-4-methyl-3-(trifluoromethyl)benzoyl chloride (CAS 1824271-04-6)
- 3-Aminoisoquinoline-8-carbonitrile (CAS 1337880-34-8)
- Tirzepatide Impurity 21 X TFA Salt (CAS CATO-C4X-324021)
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