Crisaborole Impurity 15 CAS 1187187-01-4
| CAS No. | 1187187-01-4 |
| Molecular Formula | C14H14BNO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Crisaborole Impurity 15 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Crisaborole Impurity 15 (CAS 1187187-01-4) is a certified pharmaceutical impurity reference standard with the molecular formula C14H14BNO3HCl and a molecular weight of 291.54 g/mol.
Structurally, Crisaborole Impurity 15 (C14H14BNO3HCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.5, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 291.54 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Crisaborole Impurity 15 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H14BNO3 HCl |
| Molecular Weight | 291.54 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole Impurity 64 (CAS 1160182-44-4)
- Crisaborole lmpurity 89 (CAS 1187187-13-8)
- Crisaborole Impurity 17 (CAS 1187188-59-5)
- Crisaborole Impurity 14 (CAS 1187188-60-8)
- Crisaborole Impurity 46 (CAS 1194-02-1)
- Crisaborole Impurity 65 (CAS 1217366-74-9)
- Crisaborole Impurity 42 (CAS 1260761-47-4)
- Crisaborole Impurity 40 (CAS 13321-75-0)
Recommended Standards
- Telmisartan Impurity 67 (CAS CATO-C4X-135967)
- Zidovudine Impurity 13 (CAS 123606-70-2)
- Lenalidomide Impurity 69 (CAS CATO-C4X-190369)
- methyl 4-(hydroxymethyl)-5-methylfuran-2-carboxylate (CAS 209853-87-2)
- 9-([1,1'-Biphenyl]-3-yl)-9'-([1,1':4',1''-terphenyl]-4-yl)-9H,9'H-3,3'-bicarbazole (CAS 2101561-65-1)
- 5-Cyclopropoxy-4-fluoro-2-methoxypyridine (CAS 1243481-63-1)
- 2-Methylpentane-1,2-diamine (CAS 100868-68-6)
- (3E)-3-[(2-Chlorophenyl)methylidene]-3,4-dihydro-2H-1-benzopyran-4-one (CAS 1333395-36-0)
- 1-Isobutyl-4-nitrobenzene (CAS 10342-60-6)
- Semaglutide impurity 59 (CAS CATO-C4X-222659)
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