Crisaborole Impurity 64 CAS 1160182-44-4
| CAS No. | 1160182-44-4 |
| Molecular Formula | C9H9BrO3 |
| Molecular Weight | 245.07 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Crisaborole Impurity 64.
Crisaborole Impurity 64 (CAS 1160182-44-4) is a certified pharmaceutical impurity reference standard with the molecular formula C9H9BrO3 and a molecular weight of 245.07 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system, Crisaborole Impurity 64 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 245.07 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Crisaborole Impurity 64 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C9H9BrO3 |
| Molecular Weight | 245.07 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Br-containing |
Related Crisaborole Standards
- Crisaborole lmpurity 78 (CAS 2251695-12-0)
- Crisaborole Impurity 7 (CAS 2803552-55-6)
- Crisaborole lmpurity 87 (CAS CATO-C4X-202187)
- Crisaborole impurity 161 (CAS CATO-C4X-2021161)
- Crisaborole Impurity 8 (CAS CATO-C4X-20218)
- Crisaborole Hydrate Salt (CAS 2760304-92-3)
- Crisaborole Impurity 10 (CAS 906673-42-5)
- Crisaborole Impurity 11 (CAS 943311-54-4)
Recommended Standards
- Salbutamol Intermediate Impurity 55 (CAS 62932-94-9)
- 5-Bromo-2-methoxyphenylacetic acid (CAS 7017-48-3)
- Deflazacort Impurity 91 (CAS CATO-C4X-202191)
- 6-Bromoveratraldehyde (CAS 5392-10-9)
- Cabozantinib Impurity 2 (CAS 918642-61-2)
- Osimertinib Impurity 37 (CAS CATO-C4X-204537)
- Tetracaine impurity 20 (CAS 1152620-27-3)
- n-(5-Methylthiazol-2-yl)-1h-benzo[d]imidazole-5-carboxamide (CAS 930416-08-3)
- Methyl 2-(5-methylpyridin-2-yl)acetate (CAS 19946-10-2)
- Ethyl 4-methyl-7-nitro-1H-indole-2-carboxylate (CAS 61149-52-8)
- 7-(2-Methoxyethyl)-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1h-purine-2,6-dione (CAS 730949-82-3)
- 5-(Butylamino)-1,3,4-oxadiazole-2-carboxylic acid (CAS 76368-98-4)
- 4-Methyl Histamine DiHCl (CAS 36376-47-3)
- Semaglutide Impurity 130 (CAS 1188328-40-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com